Predictive Utility of Serum Ca-125 as a Biomarker in Pre-Eclampsia
- 1. 3rd Year PG Resident, Department of Obstetrics and Gynaecology, Geetanjali Medical College and Hospital, Udaipur
- 2. Associate Professor, Department of Obstetrics and Gynaecology, Geetanjali Medical College and Hospital, Udaipur
Description
Objective: The present study aims to determine the positive predictive utility of CA-125 as a biomarker in women destined to develop pre-eclampsia. Method: After taking proper informed consent a total of 140 singleton pregnant females at or after 20 weeks were assessed for serum CA-125 at 20 weeks and followed up to term. The patients of pre-eclampsia formed one comparison group against non-pre eclamptic group. Result: There appears a strong co-relation between values of CA125 and incidence of pre-eclampsia as demonstrated by the table above and graph besides. The P value is <0.001, which is highly significant. In our study, the mean CA125 levels was 11.44 ± 4.89 IU/ml. In comparison to controls, preeclampsia patients’ mean CA125 levels were considerably higher, at 49.49 ± 21.0 IU/ml (p 0.001). Conclusion: Preeclamptic females had a mean CA-125 concentration that was substantially higher than that of normal pregnancies. A correlation between CA-125 level and the degree of pre-eclampsia was found to be positive. There exists a positive co-relation between levels of CA125, Systolic Blood Pressure, Diastolic Blood pressure, Serum uric acid and Serum Creatinine, all of which are predictors of pre-eclampsia.
Abstract (English)
Objective: The present study aims to determine the positive predictive utility of CA-125 as a biomarker in women destined to develop pre-eclampsia. Method: After taking proper informed consent a total of 140 singleton pregnant females at or after 20 weeks were assessed for serum CA-125 at 20 weeks and followed up to term. The patients of pre-eclampsia formed one comparison group against non-pre eclamptic group. Result: There appears a strong co-relation between values of CA125 and incidence of pre-eclampsia as demonstrated by the table above and graph besides. The P value is <0.001, which is highly significant. In our study, the mean CA125 levels was 11.44 ± 4.89 IU/ml. In comparison to controls, preeclampsia patients’ mean CA125 levels were considerably higher, at 49.49 ± 21.0 IU/ml (p 0.001). Conclusion: Preeclamptic females had a mean CA-125 concentration that was substantially higher than that of normal pregnancies. A correlation between CA-125 level and the degree of pre-eclampsia was found to be positive. There exists a positive co-relation between levels of CA125, Systolic Blood Pressure, Diastolic Blood pressure, Serum uric acid and Serum Creatinine, all of which are predictors of pre-eclampsia.
Files
IJPCR,Vol15,Issue5,Article245.pdf
Files
(365.4 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:89215eb87cf8942a2d2e00ae4630b5d1
|
365.4 kB | Preview Download |
Additional details
Dates
- Accepted
-
2023-04-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue5,Article245.pdf
- Development Status
- Active
References
- 1. De Swiet, Michael. Medical Disorders in Obstetrical Practice. 4th Edition, 2002. 2. Magee L. A., Helewa M., Moutquin J.- M., von Dadelszen P. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. Journal of Obstetrics and Gynaecology Canada. 2008; 30; 3. 3. Dekker G, Sibai B. Primary, secondary, and tertiary prevention of pre-eclampsia. Lancet. 2001; 357; 209-215.4. Schmidt T, Rein DT, Foth D, Eibach HW, Kurbacher CM, Mallmann P et al. Prognostic value of repeated serum CA125 measurements in first trimester of pregnancy. Eur J Obstet Gyneacol reprod Biol. 2001; 97:168-173. 5. O'Brien TJ, Hardin JW, Bannon GA, Norris JG, Quirk Jnr JG. CA125 antigen in human amniotic fluid and fetal membranes. AJOG. 1986; 155;50-55. 6. M. A. Osmanagaoglu M A, Erdogan I, Eminagaoglu S, Karahan S C, S Ozgu, G Can ̧Bozkaya H. The diagnostic value of b-human chorionic gonadotropin, progesterone, Ca125 in the prediction of abortions. J Obstet Gynecol. 2010; 30(3): 288-293. 7. Witt BR, Wolf GC, Wainwright BJ, Johnston PD, Thorneyccoft IH. Relaxin, CA125 measurements in first trimester of pregnancy. Eur J Obstet Gyneacol reprod Biol. 2001; 97:168-173. 8. Rekha Reddy, Sireesha, Manjula, Shruthi Manivikar: Significance of spot urine protein creatinine ratio versus 24-hour urinary protein analysis and their correlation in quantification of proteinuria in hypertensive pregnant women – A Prospective Observational Study; 2015. 9. Sibai BM, Barton JR: Expectant management of severe preeclampsia remote from term: patient selection treatment and delivery indication. Am J Obstet Gynacol. 2007; 196:514-516. 10. Cebesoy F B, Ozcan B, Ebru D, Hakan K, Yelda I. CA125 and CRP are Elevated in Preeclampsia. Hypertens Pregnancy. 2009; 28(2): 201-211. 11. Karaman E, Karaman Y, Alkis I, Han A, Yildrim G, Ark HC.Maternal serum CA125 level is elevated in severe preeclampsia. Preg Hyper: An Int J Women's Card health. 2013. 12. Mustafa O, Kanat-Pektas M, Okan Y, Tayfun G, Nuri D and Mollamahmutoglu L. Serum concentrations of CA125 in normal and preeclamptic pregnancies. Arch Gynecol Obstet. 2010; 284(3): 607- 612.