THE CHEMISTRY OF HEALING: HETEROATOMIC DERIVATIZATION AND THEIR MEDICINAL APPLICATIONS

Heterocyclic compounds are gaining attention for their medical and biological applications, with over 90% of new drugs containing them. Among all the heterocyclic molecules, mimics of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In the present investigation, we amalgamate isatin and several aromatic aldehydes to produce a few thiazolidinone derivatives. This synthesis aims to contribute to the ongoing progress in the development of innovative nitrogen-containing heterocycles.