Study of Serum Adenosine Deaminase (ADA) Level in FNAC Confirmed Cases of Tubercular Lymphadenitis
Authors/Creators
- 1. Post Graduate Trainee, Department of Pathology, MGM Medical College & LSK Hospital, Kishanganj
- 2. Associate Professor, Department of Pathology, MGM Medical College & LSK Hospital, Kishanganj
Description
Background: Tuberculosis is a chronic pulmonary and systemic disease that predominantly occurs due to Mycobacterium tuberculosis infection. TB is a leading health hazard globally. Tubercular lymphadenitis is the commonest type of presentation of extrapulmonary TB. The Present study was done to assess correlation between FNAC and serum ADA level in diagnosing tubercular lymphadenitis and to rule out early tuberculosis in cases reported as reactive lymphadenitis by FNAC. Materials and Methods: A two-year prospective study of 54 cases of clinically suspected tubercular lymphadenitis from December 2020 to November 2022 was done. The study subjects were first confirmed by FNAC along with AFB staining. This was followed by measurement of serum ADA levels. Results: The mean age of the patients in this study was 29 years with slight predilection for female sex. Only 24%, 13 cases present with constitutional symptoms. In cytomorphology 22 cases (40.74%) diagnosed as granulomatous lymphadenitis, while 2 cases diagnosed as reactive lymphadenitis only. Most of cases (39 cases, 72.2%) show significant increase in serum ADA level. Conclusions: FNAC along with raised serum ADA level can be considered as a reliable indicator of tubercular lymphadenitis and is fairly significant though demonstration of AFB Ziehl-Neelsen stain is gold standard.
Abstract (English)
Background: Tuberculosis is a chronic pulmonary and systemic disease that predominantly occurs due to Mycobacterium tuberculosis infection. TB is a leading health hazard globally. Tubercular lymphadenitis is the commonest type of presentation of extrapulmonary TB. The Present study was done to assess correlation between FNAC and serum ADA level in diagnosing tubercular lymphadenitis and to rule out early tuberculosis in cases reported as reactive lymphadenitis by FNAC. Materials and Methods: A two-year prospective study of 54 cases of clinically suspected tubercular lymphadenitis from December 2020 to November 2022 was done. The study subjects were first confirmed by FNAC along with AFB staining. This was followed by measurement of serum ADA levels. Results: The mean age of the patients in this study was 29 years with slight predilection for female sex. Only 24%, 13 cases present with constitutional symptoms. In cytomorphology 22 cases (40.74%) diagnosed as granulomatous lymphadenitis, while 2 cases diagnosed as reactive lymphadenitis only. Most of cases (39 cases, 72.2%) show significant increase in serum ADA level. Conclusions: FNAC along with raised serum ADA level can be considered as a reliable indicator of tubercular lymphadenitis and is fairly significant though demonstration of AFB Ziehl-Neelsen stain is gold standard.
Files
IJPCR,Vol15,Issue5,Article159.pdf
Files
(593.3 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:cd1855530eebc8fa8cbb0c9563a68ab0
|
593.3 kB | Preview Download |
Additional details
Dates
- Accepted
-
2023-04-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue5,Article159.pdf
- Development Status
- Active
References
- 1. Afrasiabian S, Mohsenpour B, Bagheri KH et al. Diagnostic value of serum adenosine deaminase level in pulmonary tuberculosis. J Res Med Sci. 2013; 18(3): 252-4. 2. Salmanzadeh S, Tavakkol H, Bavieh K et al. Diagnostic Value of Serum Adenosine Deaminase (ADA) Level for Pulmonary Tuberculosis. Jundishapur J Microbiol. 2015; 8(3): e21760. 3. Abdelsadek H, Alaarag, Osama I et al. diagnostic utility of adenosine deaminase level in the diagnosis of pulmonary tuberculosis. Egyptian J Bronchol. 2016; 10; 133-9. 4. Das DK, Pant CS, K L Chandra et al. Tuberculous lymphadenitis: correlation of cellular components and necrosis in lymph node aspirate with AFB positivity and bacillary count. Indian J Pathol Microbiol. 1990; 33; 1-10. 5. Klockars M, Kleemola M, Leinomen M et al. Serum adenosine deaminase in viral and bacterial pneumonia. Chest. 1988; 94: 1315. 6. Greco S, Girardi E, Masciangelo R et al Adenosine Deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a metanalysis. Int J Tuberc Lung Dis. 2003; 7(8): 777-86. 7. Lalvani A, A A Pathan, H McShane et al. Rapid detection of Mycobacterium tuberculosis infection by numeration of antigen-specific T cells Am. J Respir Crit Care Med. 2001; 163: 824-8. 8. Ammari F F, Bani A H and Ghariebeh K I. Tuberculosis of the lymph glands of the neck: a limited role for surgeryOtolaryngol Head Neck Surg. 2003; 128(4): 576-80. 9. Stevanovic G, Pelemis M, Pavlovic M et al. Significance concentration in the diagnosis of Extra Pulmonary Tuberculosis- J of IMAB. 2011; 17(1): 130-4. 10. Grange J, Zumla, A. The global emergency of tuberculosis: what is the cause? SAGE Journal. 2002; 122: 78-81. 11. Piras MA, Gakis C, Budroni M et al. Adenosine deaminase activity in pleural effusions: An aid to differential diagnosis. Br Med J. 1978; 2:1751–2. 12. Tuon FF, Silva VI, Almeida GM et al. The usefulness of adenosine deaminase in the diagnosis of tuberculous pericarditis. Rev Inst Med Trop Sao Paulo. 2007; 49: 165–70. 13. Mathur M, Pandey SN. Clinicopathological profile of cutaneous tuberculosis in central Nepal. Kathmandu Univ Med J. 2014; 48(4): 238-41. 14. Khanna R, Prasanna GV, Gupta P et al. Mammary tuberculosis: report on 52 cases. Postgrad Med J. 2002; 78: 422-4. 15. Chowdhury NNR. Overview of Tuberculosis of the female genital tract. J Indian Med Assoc. 1996; 94: 345-6. 16. Mugulkod P, Chavan S. Serum adenosine levels and other laboratory parameters in the diagnosis of extrapulmonary tuberculosis: a clinicopathological study. Int J Res Med Sci. 2017; 5(7): 3140-8. 17. Garg I, Arora D. Association of serum adenosine deaminase levels in cytologically suggested cases of tubercular lymphadenitis: The experience of a tertiary care centre SJMS. 2021; 16(3); 386-98. 18. Radhika S, Rajwanshi A, Kochhar R et al. Abdominal tuberculosis; diagnosis by fine needle aspiration cytology. Acta Cytol. 1993; 37: 673-8. 19. Agarwal MK, Nath J, Mukerji PK, et al. A Study of Serum Adenosine Deaminase Activity in Sputum Negative Patients of Pulmonary Tuberculosis. Ind J Tub. 1991; 38(1): 139–41. 20. Verma M, Narang S, Moonat A et al. Study of adenosine deaminase activity in pulmonary tuberculosis and other common respiratory diseases. Ind J Clin Biochem. 2004; 19(1): 129-31. 21. Jhamaria JP, Jenaw RK, Luh SK et al. Serum adenosine deaminase (ADA) in differential diagnosis of Pulmonary Tuberculosis and common nonTuberculosis respiratory diseases. Ind J Tub. 1988; 35: 25-7.