A Randomized Comparative Clinical Assessment of Postoperative Analgesic Efficacy of Epidural Ropivacaine and Ropivacaine with Tramadol in Patients Undergoing Abdominal Surgeries: A Prospective Clinical Study

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Abstract (English)

Abstract
Aim: The aim of the study was to compare the postoperative analgesic efficacy of epidural
Ropivacaine and Ropivacaine with Tramadol in adults undergoing abdominal surgeries under
general anesthesia.
Methods: The study was a prospective randomized, double arm, single-blind, controlled study.
The study was conducted in patients scheduled for abdominal surgeries done under general
anesthesia at Anugrah Narayan Magadh Medical College and Hospital, Gaya, India for one
year.The sample size was determined based on the study. In our study, 50 subjects were
included.
Results: In our study while analyzing the age distribution, in the Ropivacaine group, the
majority of the study subjects belonged to the 31-40 years age class interval (n=10, 40%) with
a mean age of 43.07 years. In patients belonging to Ropivacaine group, the majority of the
study subjects belonged to ≤ 240 minutes duration of postoperative analgesia class interval
(n=24, 96%) with a mean duration of postoperative analgesia of 220.57 minutes. In the
Ropivacaine with Tramadol group majority belonged to 300-360 minutes duration of
postoperative analgesia class interval (n=15, 60%). The association between heart rate
distribution and intervention groups is considered to be non-significant since p-value was >
0.05 as per unpaired t-test. The association between mean peripheral capillary oxygen
saturation distribution and intervention groups is considered to be nonsignificant since p-value
was > 0.05 as per unpaired t-test. The association between mean respiratory rate distribution
and intervention groups is considered to be nonsignificant since p-value was > 0.05 as per
unpaired t-test.
Conclusion: We concluded that the addition of 1 mg/kg of Tramadol improves the
postoperative analgesic efficacy of epidural 0.2% Ropivacaine by prolonging the duration of
analgesia and providing good sedation with no significant hemodynamic alterations, nausea,
vomiting and pruritus.