An Experiment Comparative Assessment of Intranasal Steroids Sprays Alone V/S Intranasal Steroids with Intranasal Antihistamines Sprays in Patients with Allergic Rhinitis

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Abstract (English)

Abstract
Aim: The aim of the present study was to compare intranasal steroids sprays alone v/s intranasal steroids with
intranasal antihistamines sprays in patients with allergic rhinitis.
Methods: The Present study was conducted in Department of ENT, GMERS Medical College, Himmatnagar,
Gujarat, India. Study type was comparative, prospective study of one year duration.
Results: In present study, 200 patients were randomly divided in group A (n=100) and group B (n=100). Majority
of the patients belonged to 18-25 years age group. Age and gender distribution was comparable among both groups
and difference was not significant statistically. All the parameters of TNSS before treatment, after 2weeks of
treatment and after 4 weeks of treatment were analysed using ANOVA test (as it was found to be parametric in
distribution) in the subjects treated with combination therapy and it was noted that statistically significant
difference was found in all the parameters of all three groups (p < 0.0001). It was found that two groups were
matched for activities, practical problem, nose symptoms, other symptoms. Eye symptoms were found to be
significantly higher in steroid therapy group compared to combination therapy group. It was observed that in the
steroid therapy group, mean percentage improvement was found to be 16% (0 weeks to 2 weeks) and 4% (2 weeks
to 4 weeks) whereas for combination therapy group, the same was found to be 30% (0 weeks to 2 weeks) and 22%
(2 weeks to 4 weeks).
Conclusion: The management of AR includes patient education on avoidance of allergen as well as
pharmacotherapy and allergen specific immunotherapy. Combination of intranasal steroids with intranasal
antihistamines sprays has significant reduction of symptoms when compared to intranasal steroids spray alone.