Serum Fructosamine: A Novel Marker for Assessing the Severity of Alcoholic Liver Disease

Description

Abstract (English)

Abstract
Background and Objectives: The present investigation seeks to assess the utility of serum Fructosamine and
glycated hemoglobin (HbA1C) as indicators for evaluating glycemic regulation and determining the severity and
prognostic implications of chronic alcoholic liver disease. The central objective of this study is to discern the
preeminent marker, either HbA1C or Fructosamine, for delineating these parameters within the context of
chronic alcoholic liver disease.
Methods: A cohort of 110 individuals aged between 20 and 70 years, who were diagnosed with chronic
alcoholic liver disease, constituted the study populace. Additionally, 55 age and gender-matched healthy
subjects were enlisted as controls. Within the patient cohort, further stratification into non-complicated and
complicated subgroups was performed. Measurement of HbA1C levels was executed through the
immunoturbidimetry technique, while serum Fructosamine levels were quantified using colorimetry employing
nitro blue tetrazolium. The quantification of serum glutamic oxaloacetic transaminase (SGOT) adhered to the
IFCC methodology, while serum total protein concentrations were determined via the biuret method.
Results: In both the non-complicated and complicated chronic alcoholic liver disease patient cohorts, mean
concentrations of HbA1C and serum total protein exhibited a decrement, whereas mean concentrations of serum
Fructosamine and SGOT demonstrated an elevation. Notably, no statistically significant variance in serum total
protein levels was discerned between non-complicated cases and control subjects. The mean HbA1C value
displayed no substantial disparity between non-complicated and complicated cases. Noteworthy correlations
surfaced, wherein SGOT evinced a notable inverse correlation with serum total protein, a significant direct
correlation with serum Fructosamine, and no discernible correlation with HbA1C. Furthermore, a significant
negative correlation materialized between serum total protein and serum Fructosamine.
Conclusion: The findings of this research elucidate that serum Fructosamine surpasses HbA1C as a more
efficacious marker for monitoring chronic glycemic regulation and gauging the severity of chronic alcoholic
liver disease. These results underscore the pivotal role of serum Fructosamine in clinical assessments within the
purview of chronic alcoholic liver disease and its metabolic ramifications