FORMULATION AND EVALUATION OF FLOATING FENOVERINE TABLETS

Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Fenoverine were prepared by direct compression method using altered concentrations of Carbopol, HPMC K 100 and Ethyl Cellulose as polymers. The prepared tablets of Fenoverine were evaluated tablet hardness, uniformity of weight, friability, uniformity of content, in vitro buoyancy test and in vitro dissolution study. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution studies, dissolution parameters and drug released mechanisms. F5 formulation showed maximum floating time of 12 hours and gave slow and maximum drug release of Fenoverine spread over 12 hours. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.