A Prospective Investigation of Low-Dose Aspirin Treatment and Renal Function in the Geriatric Patients
- 1. Assistant professor, Department of General medicine, ICARE Institute of Medical Sciences and Research And Dr. Bidhan Chandra Roy Hospital, Haldia, West Bengal, India.
- 2. Associate professor, Department of General medicine, Shri Ramkrishna Institute of Medical Sciences and Sanaka Hospital, Durgapur, West Bengal, India.
Description
Aim: The aim of this study to evaluate the low dose aspirin therapy and renal function in elderly patients. Methods: This prospective study was carried out in the Department of General medicine, ICARE Institute of Medical Sciences and Research And Dr. Bidhan Chandra Roy Hospital, Haldia, West Bengal, India for 1 year. This study employed a cohort of 50 elderly patients (age 60 years) and was comprised of 30 male and 20 female patients at the commencement of the study. The United Nations definition of an elderly person was used. Results: A total of 50 participated in this preliminary study. There were 20 (40%) females and 30 (60%) males with age range between 50–80 years and mean ages of 59.88 years (±7.16) and 65.77 years (±10.09) for males and females, respectively. 21 (42%) of the patients had more than one diagnosis. Systemic hypertension was the most common diagnosis, accounting for 31 (62%) of cases. Hypertension and diabetes mellitus coexisted in seven (24%) of the study participants. 88% exhibited their basal renal function in stages 1 and 2 based on CrCl. The P-value for all these weekly parameters did not show statistical significance except for the CrCl (P = 0.021). The CrCl reduced at week 2, and then increased at week 3, pleateauing before gradually returning to baseline at the sixth week. The mean hemoglobin was 12.7 ± 5.7 g/dL with a range of 7.7–15.7 g/Dl. Conclusion: This study did not show any deleterious effects of short-term, low dose aspirin (75 mg) use on the renal function of elderly patients. This 6-week study was cumbersome for most of the patients, and this precluded the participation of a lot of eligible geriatric patients.
Abstract (English)
Aim: The aim of this study to evaluate the low dose aspirin therapy and renal function in elderly patients. Methods: This prospective study was carried out in the Department of General medicine, ICARE Institute of Medical Sciences and Research And Dr. Bidhan Chandra Roy Hospital, Haldia, West Bengal, India for 1 year. This study employed a cohort of 50 elderly patients (age 60 years) and was comprised of 30 male and 20 female patients at the commencement of the study. The United Nations definition of an elderly person was used. Results: A total of 50 participated in this preliminary study. There were 20 (40%) females and 30 (60%) males with age range between 50–80 years and mean ages of 59.88 years (±7.16) and 65.77 years (±10.09) for males and females, respectively. 21 (42%) of the patients had more than one diagnosis. Systemic hypertension was the most common diagnosis, accounting for 31 (62%) of cases. Hypertension and diabetes mellitus coexisted in seven (24%) of the study participants. 88% exhibited their basal renal function in stages 1 and 2 based on CrCl. The P-value for all these weekly parameters did not show statistical significance except for the CrCl (P = 0.021). The CrCl reduced at week 2, and then increased at week 3, pleateauing before gradually returning to baseline at the sixth week. The mean hemoglobin was 12.7 ± 5.7 g/dL with a range of 7.7–15.7 g/Dl. Conclusion: This study did not show any deleterious effects of short-term, low dose aspirin (75 mg) use on the renal function of elderly patients. This 6-week study was cumbersome for most of the patients, and this precluded the participation of a lot of eligible geriatric patients.
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Additional details
Dates
- Accepted
-
2022-04-18
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References
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