Prevalence of Pseudomonas aeruginosa and its Antimicrobial Sensitivity Profile among Postoperative Wound Infections in a Tertiary Care Hospital
Authors/Creators
- 1. Tutor, Department of Microbiology, Nalanda Medical College Hospital Patna, Bihar, India
- 2. Junior Resident, Department of Microbiology, Nalanda Medical College Hospital Patna, Bihar, India
- 3. Assistant Professor, Department of Microbiology, Nalanda Medical College Hospital Patna, Bihar, India
Description
Background: Postoperative wound infections significantly contribute to morbidity and healthcare costs in tertiary care facilities. Awareness of the antibiotic resistance profile of Pseudomonas aeruginosa in these diseases is necessary to develop effective treatment options and infection control measures. Methods: In a tertiary care hospital, a retrospective observational study spanning from July 2022 to June 2023 was conducted. Patients with surgical incisions who were infected met the inclusion criteria. Protocols for antimicrobial treatment, lesion characteristics, culture and sensitivity data, and patient demographics were all documented. Patterns of antimicrobial susceptibility were identified through descriptive data analysis. Results: Pseudomonas aeruginosa was isolated from 90 of 300 cases of studied postoperative wound infections for a prevalence incidence of 30%. Most Pseudomonas aeruginosa isolates (n=125; 83.3%) were isolated from surgical sites, whereas the remaining isolates were isolated from deep wounds. Pseudomonas aeruginosa exhibited a high level of resistance to commonly prescribed antibiotics, such as ciprofloxacin (68%), ceftazidime (62%), and gentamicin (55%). In contrast, its sensitivity to carbapenems was elevated, with 78% and 75% sensitivity to meropenem and imipenem, respectively. Conclusion: Pseudomonas aeruginosa is a leading cause of surgical wound infections in our tertiary care hospital, and many of the isolates have developed resistance to standard antibiotic treatment. The alarmingly high resistance rates, antimicrobial stewardship and exploring novel therapeutic approaches, such as carbapenems, are necessary. These findings highlight the significance of infection control and surveillance strategies for reducing the prevalence of Pseudomonas aeruginosa in surgical wound infections and enhancing patient outcomes.
Abstract (English)
Background: Postoperative wound infections significantly contribute to morbidity and healthcare costs in tertiary care facilities. Awareness of the antibiotic resistance profile of Pseudomonas aeruginosa in these diseases is necessary to develop effective treatment options and infection control measures. Methods: In a tertiary care hospital, a retrospective observational study spanning from July 2022 to June 2023 was conducted. Patients with surgical incisions who were infected met the inclusion criteria. Protocols for antimicrobial treatment, lesion characteristics, culture and sensitivity data, and patient demographics were all documented. Patterns of antimicrobial susceptibility were identified through descriptive data analysis. Results: Pseudomonas aeruginosa was isolated from 90 of 300 cases of studied postoperative wound infections for a prevalence incidence of 30%. Most Pseudomonas aeruginosa isolates (n=125; 83.3%) were isolated from surgical sites, whereas the remaining isolates were isolated from deep wounds. Pseudomonas aeruginosa exhibited a high level of resistance to commonly prescribed antibiotics, such as ciprofloxacin (68%), ceftazidime (62%), and gentamicin (55%). In contrast, its sensitivity to carbapenems was elevated, with 78% and 75% sensitivity to meropenem and imipenem, respectively. Conclusion: Pseudomonas aeruginosa is a leading cause of surgical wound infections in our tertiary care hospital, and many of the isolates have developed resistance to standard antibiotic treatment. The alarmingly high resistance rates, antimicrobial stewardship and exploring novel therapeutic approaches, such as carbapenems, are necessary. These findings highlight the significance of infection control and surveillance strategies for reducing the prevalence of Pseudomonas aeruginosa in surgical wound infections and enhancing patient outcomes.
Files
IJPCR,Vol15,Issue7,Article131.pdf
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Additional details
Dates
- Accepted
-
2023-05-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article131.pdf
- Development Status
- Active
References
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