Effect of Dexmedetomide & Propofol on Haemodynamic Response During Tracheal Extubation among Hypertensive Patients – A Comparative Study
Creators
- 1. Senior Resident, Anesthesia Department, GMERS Medical College, Dharpur, Patan, Gujarat, India
- 2. Assistant Professor, Anesthesia Department, GMERS Medical College, Dharpur, Patan, Gujarat, India
- 3. Senior resident, Anesthesia department, GMERS Medical College, Dharpur, Patan, Gujarat, India
- 4. Assistant Professor, Anesthesia department, GMERS Medical College, Dharpur, Patan, Gujarat, India
- 5. Professor, Anesthesia Department, IKDRC-ITC, BJ Medical College, Ahmedabad, Gujarat, India
- 6. Professor and Head, Anesthesia department, IKDRC-ITC, BJ Medical College, Ahmedabad, Gujarat, India
- 7. Assistant Professor, Community Medicine department, Banas Medical College and Research Institute, Palanpur, Gujarat, India
Description
Background: Recovery from general anaesthesia and tracheal extubation is often accompanied with tachycardia and hypertension which may cause myocardial ischemia or infarction in susceptible patients. Propofol and Dexmedetomidine have been studied seperately in attenuating pressure response during extubation, quality of extubation and postoperative sedation in normotensive patients but these two drugs have been compared rarely in hypertensive patients. Objective: This study was conducted with objective of to compare hemodynamic changes (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure) during tracheal extubation after general anaesthesia between two groups. Materials and Methods: Prospective observational comparative study was carried out at tertiary care hospital in Central Gujarat between July 2017 to October 2019. Results: It can effectively be concluded that Propofol (0.5 mg/kg) 2 min prior to extubation and Dexmedetomidine (0.5µg/kg) infusion 10 min before extubation both are safe and efficacious in attenuating the hemodynamic stress response during extubation. Dexmedetomidine is better at controlling HR, DBP, MAP than Propofol. Conclusion: Dexmedetomidine is an effective and safe drug to provide stable hemodynamics and protects against the stress response to extubation.
Abstract (English)
Background: Recovery from general anaesthesia and tracheal extubation is often accompanied with tachycardia and hypertension which may cause myocardial ischemia or infarction in susceptible patients. Propofol and Dexmedetomidine have been studied seperately in attenuating pressure response during extubation, quality of extubation and postoperative sedation in normotensive patients but these two drugs have been compared rarely in hypertensive patients. Objective: This study was conducted with objective of to compare hemodynamic changes (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure) during tracheal extubation after general anaesthesia between two groups. Materials and Methods: Prospective observational comparative study was carried out at tertiary care hospital in Central Gujarat between July 2017 to October 2019. Results: It can effectively be concluded that Propofol (0.5 mg/kg) 2 min prior to extubation and Dexmedetomidine (0.5µg/kg) infusion 10 min before extubation both are safe and efficacious in attenuating the hemodynamic stress response during extubation. Dexmedetomidine is better at controlling HR, DBP, MAP than Propofol. Conclusion: Dexmedetomidine is an effective and safe drug to provide stable hemodynamics and protects against the stress response to extubation.
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Additional details
Dates
- Accepted
-
2022-06-05
Software
References
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