A Study Assessing the Association between Antibody Titers and Nutritional Status in Paediatric Population Diagnosed with Measles
Creators
- 1. Senior Resident, Department of Pediatrics, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, Delhi, India
- 2. Senior Resident, Department of Pediatrics, RKM Seva Pratishthan, Kolkata, West Bengal, India
Description
Abstract
Aim: The aim of the present study was to find out any association of measles antibody titres with nutritional
status in children 1 to 12 years.
Methods: This hospital based cross-sectional study was conducted in the duration of 12 months on 1–12-yearold children attending the Pediatric O.P.D. of Department of Pediatrics, Department of Pediatrics, Dr.Baba
Saheb Ambedkar Medical College and Hospital, Rohini, Delhi, India with the objective of finding out the
seroprevalence and anti-measles antibody levels, and studying their association with age, gender, as well as
nutritional status of these children.
Results: Majority (70%) of the total subjects had been vaccinated against measles. However, the relationship
between age and vaccination status was not found to be statistically significant (p=0.155). No statistically
significant difference was observed in the baseline characteristics of vaccinated and unvaccinated group except
for mean weight for age Z score which was significantly lower in the unvaccinated group. 41% of the total
subjects ≤5 years old had severe wasting (severe acute malnutrition), while 32% had moderate wasting. In
children > 5 years, 22% had severe thinness, 11.60% had thinness and only 2 (0.2%) case was overweight.
42.85% of the vaccinated subjects ≤5 years old had severe wasting (severe acute malnutrition), while 34.28%
had moderate wasting. A highly statistically significant relationship was observed between BMI Z scores (in
subjects aged ≥5yrs) and seropositivity, with higher seropositivity being noted in children with higher BMI z
scores. Similarly, a statistically significant relationship was observed between height for age Z scores and
seropositivity, with higher seropositivity being noted in children with higher height for age z scores.
Conclusion: Nutritional status of children has an association with measles antibody titres as well GMT of
measles specific IgG antibody, with those with better nutritional status having higher measles antibody titres
Abstract (English)
Abstract
Aim: The aim of the present study was to find out any association of measles antibody titres with nutritional
status in children 1 to 12 years.
Methods: This hospital based cross-sectional study was conducted in the duration of 12 months on 1–12-yearold children attending the Pediatric O.P.D. of Department of Pediatrics, Department of Pediatrics, Dr.Baba
Saheb Ambedkar Medical College and Hospital, Rohini, Delhi, India with the objective of finding out the
seroprevalence and anti-measles antibody levels, and studying their association with age, gender, as well as
nutritional status of these children.
Results: Majority (70%) of the total subjects had been vaccinated against measles. However, the relationship
between age and vaccination status was not found to be statistically significant (p=0.155). No statistically
significant difference was observed in the baseline characteristics of vaccinated and unvaccinated group except
for mean weight for age Z score which was significantly lower in the unvaccinated group. 41% of the total
subjects ≤5 years old had severe wasting (severe acute malnutrition), while 32% had moderate wasting. In
children > 5 years, 22% had severe thinness, 11.60% had thinness and only 2 (0.2%) case was overweight.
42.85% of the vaccinated subjects ≤5 years old had severe wasting (severe acute malnutrition), while 34.28%
had moderate wasting. A highly statistically significant relationship was observed between BMI Z scores (in
subjects aged ≥5yrs) and seropositivity, with higher seropositivity being noted in children with higher BMI z
scores. Similarly, a statistically significant relationship was observed between height for age Z scores and
seropositivity, with higher seropositivity being noted in children with higher height for age z scores.
Conclusion: Nutritional status of children has an association with measles antibody titres as well GMT of
measles specific IgG antibody, with those with better nutritional status having higher measles antibody titres
Files
IJCPR,Vol15,Issue9,Article1.pdf
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Additional details
Dates
- Accepted
-
2023-04-20