Evaluation of Maternal and Neonatal Risk Factors and Outcomes of EOS

Description

Abstract (English)

Abstract:
Introduction: Maternal and neonatal risk factors affect the development of “early-onset sepsis (EOS)” in infants.
Group B Streptococcus infection and preterm membrane rupture are two examples of maternal causes. Prematurity, low birth weight, and mother colonization are all factors that pose a danger to newborns. Preventing EOS
and its severe repercussions, like septic shock and long-term developmental difficulties, requires prompt diagnosis
and treatment.
Aim and Objectives: This study aims to evaluate the impact of various maternal and neonatal variables on the
outcomes of early-onset sepsis.
Method: From September 2014 to August 2015, K.G. Medical University's Lucknow NICU observed term and
preterm infants at risk of Early-Onset Sepsis. Babies who left the NICU within 24 hours or died were eliminated.
Antenatal, peripartum, maternal, and neonatal EOS risk factors and pre-admission antibiotic exposure were examined. For a better understanding of NICU EOS, neonates were divided into “High Suspicion of EOS (HSEOS)” and Low Suspicion groups.
Result: Figure 1 and Table 1 shows culture-positive “Early-Onset Sepsis (EOS)” and neonatal EOS isolates.
Table 2 shows antibiotic susceptibility for treatment decisions. Table 3 shows baseline commonalities in cultureproven and most probable EOS newborns. Table 4 lists frequent EOS symptoms. Figure 2 stresses TLC's role in
culture-proven sepsis detection. Figure 3 shows neonatal pneumonia risk factors. Table 5 and 6 shows maternal
neonatal meningitis risk factors and early diagnosis and treatment enhance newborn outcomes for culture-positive
EOS.
Conclusion: Escherichia coli and Staphylococcus aureus cause most NICU early-onset sepsis; ampicillin, cephalosporin, and amoxicillin resistance is widespread; piperacillin and amikacin are first-line treatments.