Metabolic Syndrome a Risk Factor of Nephrolithiasis: A Case Control Study
- 1. Senior Resident, Department of Genito Urinary Surgery and Renal Transplantation, Govt. T.D. Medical College, Alappuzha Kerala
- 2. Professor and Head, Department of Genito Urinary Surgery and Renal Transplantation, Govt. T.D. Medical College, Alappuzha Kerala
Description
Background: This study was conducted to determine as to whether metabolic syndrome is a risk factor for nephrolithiasis among patients and whether individual components of metabolic syndrome are risk factors for nephrolithiasis. Methods: This was a hospital-based case control study conducted among 238 patients who underwent evaluation for the presence of metabolic syndrome at the Department of Urology, Governmental Medical College Alappuzha, over a period of 18 months after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: A total of 238 patients were enrolled in the study after counselling and informed consent. 119 had ultrasound-proven nephrolithiasis, and the rest of the patients were controls. All were evaluated for components of metabolic syndrome. The average age of patients was 43.45, waist circumference was 95.01, BMI was 22.82, systolic BP was 129.01, diastolic BP was 79.99, FBS was 91.58, HDL was 49.91 and triglycerides was 151.68. Male predominance was noted with 77.3 percent of participants enrolled in the study. Primary outcome: metabolic syndrome as a risk factor for nephrolithiasis is proven with a p-value of 0.008. Secondary outcomes: obesity and dyslipidemia were proven to be independent risk factors with a p-value <0. 001. However hypertension and diabetes mellitus do not independently increase the risk of nephrolithiasis. Conclusion: Metabolic syndrome when present acts as a risk factor for nephrolithiasis and components of the syndrome obesity and dyslipidemia are independent risk factors. Hypertension and diabetes mellitus do not form independent risk factors.
Abstract (English)
Background: This study was conducted to determine as to whether metabolic syndrome is a risk factor for nephrolithiasis among patients and whether individual components of metabolic syndrome are risk factors for nephrolithiasis. Methods: This was a hospital-based case control study conducted among 238 patients who underwent evaluation for the presence of metabolic syndrome at the Department of Urology, Governmental Medical College Alappuzha, over a period of 18 months after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: A total of 238 patients were enrolled in the study after counselling and informed consent. 119 had ultrasound-proven nephrolithiasis, and the rest of the patients were controls. All were evaluated for components of metabolic syndrome. The average age of patients was 43.45, waist circumference was 95.01, BMI was 22.82, systolic BP was 129.01, diastolic BP was 79.99, FBS was 91.58, HDL was 49.91 and triglycerides was 151.68. Male predominance was noted with 77.3 percent of participants enrolled in the study. Primary outcome: metabolic syndrome as a risk factor for nephrolithiasis is proven with a p-value of 0.008. Secondary outcomes: obesity and dyslipidemia were proven to be independent risk factors with a p-value <0. 001. However hypertension and diabetes mellitus do not independently increase the risk of nephrolithiasis. Conclusion: Metabolic syndrome when present acts as a risk factor for nephrolithiasis and components of the syndrome obesity and dyslipidemia are independent risk factors. Hypertension and diabetes mellitus do not form independent risk factors.
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IJPCR,Vol15,Issue7,Article57.pdf
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Additional details
Dates
- Accepted
-
2023-07-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article57.pdf
- Development Status
- Active
References
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