Epidemiological and Histopathological Study of Renal Cell Carcinoma - A Single Center Experience
Authors/Creators
- 1. Additional Professor, Department of Urology, IGIMS Patna, Bihar, India
- 2. Consultant, Department of Urology, Mahavir Cancer Sansthan, Patna, Bihar, India
- 3. 4 Senior Resident, Department of Urology, IGIMS Patna, Bihar, India
Description
Abstract
Aim: The aim of the present study was to assess the epidemiological and histopathological study of renal cell
carcinoma.
Methods: The present study was conducted at department of Urology, IGIMS Patna, Bihar, India and included
all patients who have received the diagnostic code of RCC in agreement with the International Classification of
Diseases (ICD-10) system and underwent contrast-enhanced computed tomography of the abdomen and
nephrectomy over 5-years using the electronic hospital information system (HIS). The study included 100 patients
with histologically confirmed renal cell carcinoma.
Results: 45% of the cases were elder (≥60 years), and 40% were between 40–59 years, while 15% of the patients
were younger than 40 years. The gender distribution of RCC was 70% male and 30% female. The right kidney
harbored most of the masses in 58%, 40% in the left, while 2% were bilateral involvement. Clear cell RCC was
the most common histological type in about 69%, followed by papillary RCC (14%), unclassified RCC (10%),
and Chromophobe RCC was the least common in 7% of the cases. Half of the patients held tumor stage 2, followed
by T1 in 22%, 15% in T4, and 13% in T3. WHO/ISUP grading system revealed that 47% patients had high-grade
tumors (G4 in 27% and G3 in 20%), while the remaining 53% had low-grade tumors (G2 in 45% and G1 in 8%).
Assessment of gender variation of tumor stage, grade, and comorbidities revealed a statistically significant
difference between the pattern of stage and grade of RCC and gender group.
Conclusion: The young patients had a higher tumour stage. Clear cell RCC was the most common histologic
type, though less common than that is reported in literature. Less access to the health services and facilities, the
absence of the awareness of the population, limited availability of endourological equipment, inadequate expertise
and imaging modalities, a far distance from health services, and the low socioeconomic status lead to most of the
patients living in low-income countries presenting with advanced diseases.
Abstract (English)
Abstract
Aim: The aim of the present study was to assess the epidemiological and histopathological study of renal cell
carcinoma.
Methods: The present study was conducted at department of Urology, IGIMS Patna, Bihar, India and included
all patients who have received the diagnostic code of RCC in agreement with the International Classification of
Diseases (ICD-10) system and underwent contrast-enhanced computed tomography of the abdomen and
nephrectomy over 5-years using the electronic hospital information system (HIS). The study included 100 patients
with histologically confirmed renal cell carcinoma.
Results: 45% of the cases were elder (≥60 years), and 40% were between 40–59 years, while 15% of the patients
were younger than 40 years. The gender distribution of RCC was 70% male and 30% female. The right kidney
harbored most of the masses in 58%, 40% in the left, while 2% were bilateral involvement. Clear cell RCC was
the most common histological type in about 69%, followed by papillary RCC (14%), unclassified RCC (10%),
and Chromophobe RCC was the least common in 7% of the cases. Half of the patients held tumor stage 2, followed
by T1 in 22%, 15% in T4, and 13% in T3. WHO/ISUP grading system revealed that 47% patients had high-grade
tumors (G4 in 27% and G3 in 20%), while the remaining 53% had low-grade tumors (G2 in 45% and G1 in 8%).
Assessment of gender variation of tumor stage, grade, and comorbidities revealed a statistically significant
difference between the pattern of stage and grade of RCC and gender group.
Conclusion: The young patients had a higher tumour stage. Clear cell RCC was the most common histologic
type, though less common than that is reported in literature. Less access to the health services and facilities, the
absence of the awareness of the population, limited availability of endourological equipment, inadequate expertise
and imaging modalities, a far distance from health services, and the low socioeconomic status lead to most of the
patients living in low-income countries presenting with advanced diseases.
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IJCPR,Vol15,Issue11,Article76.pdf
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Additional details
Dates
- Accepted
-
2023-10-26