ASSESSMENT OF INSULIN RESISTANCE INDEX (HOMA-IR) AND LIPID PROFILE AMONG SUDANESE WOMEN WITH GALLSTONES.

The aim of this study was to assess insulin resistance index (HOMA-IR) and lipid profile level in Sudanese gallstones (GSs) patients and their association with study variables. In case control study 80 clinically diagnosed GSs patients were recruited, and 80 apparently health age matched women as control group. Fasting insulin, glucose and lipid profile (TC, TG, HDL-C and LDL-C) were measured using TOSOH-311? and Mindray-380? analyzers. IR-index was calculated using HOMA-IR formula. Obese postmenopausal women had higher GS (62.5%). HOMA-IR, TC, LDL-C and TG level were significantly increased in Sudanese women with GS than control group p=0.000, 0.000, 0.000 and 0.000 respectively. Significant positive associations between TC, LDL-C and HOMA-IR were observed p=0.001, r=437 and p=0.001, r=0.419 respectively. BMI also showed positive association with TC, TG and LDL-C. In conclusion, Sudanese females with GSs had higher HOMA-IR, TC, TG and LDL-C. Obesity may be the first risk factor of GS in Sudanese women. Thus could lead to GSs pathogenesis especially in postmenopausal.