Incidence and Clinicopathological Assessment of Endometrial Carcinoma and their Precursor Lesions in a Tertiary Care Hospital
Creators
- 1. Assistant Professor, Department of Pathology, KAPV Government Medical College, Tiruchirapalli
- 2. Assistant Professor, Department of Pathology, Chengalpattu Medical College, Chengalpattu
- 3. Professor, Department of Pathology, Institute of Social Obstetrics & Govt. Kasturba Gandhi Hospital for Women and Children, Madras Medical College
Description
Introduction: Endometrial cancer is the commonest gynaecologic malignancy in developed countries. Hyperplasia of endometrium with atypia carries increased risk of 29% of transforming to malignancy. There is morphological overlap between atypical hyperplasia and well differentiated carcinoma making their histological differentiation, a diagnostic problem especially in curetting specimens. This distinction has clinical significance and this study is aimed to observe the incidence, distribution and clinicopathological profile of endometrial hyperplasias and endometrial carcinoma in patients who attended Institute of Social Obstetrics & Govt. Kasturba Gandhi Hospital for Women and Children, Madras Medical College for a period of 3 years. Materials And Methods: Total of 7229 cases were received for histopathological examination of these cases 3554 were endometrium specimens. 186 cases accounts for hyperplasias and malignancies of Endometrium. Among 186 cases of Endometrial hyperplasias and carcinomas, 135 cases were hyperplasias, 51 cases were malignancies. Observation and Results: Hyperplasia of Endometrium showed a peak incidence in the age group of 41 to 50 years. Carcinoma endometrium had a peak incidence age group of 51-60 years of the 135 cases of hyperplasia, 12 cases were hyperplasia with atypia. Among the 51 cases of malignancy, majority are typical endometrioid type(36 cases-70.58%), 14 were villoglandular variant(14 cases- 27.45%), 1 case was carcinosarcoma (1.96%) Of the 51 cases, majority of the cases presented in grade 1and stage I. Conclusion: To conclude the incidence of endometrial carcinoma was lower in this study compared to western population.
Abstract (English)
Introduction: Endometrial cancer is the commonest gynaecologic malignancy in developed countries. Hyperplasia of endometrium with atypia carries increased risk of 29% of transforming to malignancy. There is morphological overlap between atypical hyperplasia and well differentiated carcinoma making their histological differentiation, a diagnostic problem especially in curetting specimens. This distinction has clinical significance and this study is aimed to observe the incidence, distribution and clinicopathological profile of endometrial hyperplasias and endometrial carcinoma in patients who attended Institute of Social Obstetrics & Govt. Kasturba Gandhi Hospital for Women and Children, Madras Medical College for a period of 3 years. Materials And Methods: Total of 7229 cases were received for histopathological examination of these cases 3554 were endometrium specimens. 186 cases accounts for hyperplasias and malignancies of Endometrium. Among 186 cases of Endometrial hyperplasias and carcinomas, 135 cases were hyperplasias, 51 cases were malignancies. Observation and Results: Hyperplasia of Endometrium showed a peak incidence in the age group of 41 to 50 years. Carcinoma endometrium had a peak incidence age group of 51-60 years of the 135 cases of hyperplasia, 12 cases were hyperplasia with atypia. Among the 51 cases of malignancy, majority are typical endometrioid type(36 cases-70.58%), 14 were villoglandular variant(14 cases- 27.45%), 1 case was carcinosarcoma (1.96%) Of the 51 cases, majority of the cases presented in grade 1and stage I. Conclusion: To conclude the incidence of endometrial carcinoma was lower in this study compared to western population.
Files
IJPCR,Vol15,Issue8,Article105.pdf
Files
(2.7 MB)
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Additional details
Dates
- Accepted
-
2023-07-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue8,Article105.pdf
- Development Status
- Active
References
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