The influence of adrenalin and pilocarpin oral gel on rat parodonte state

Batig V. M., Borysenko A. V., Levitsky A. P. The influence of adrenalin and pilocarpin oral gel on rat parodonte state. Journal of Education, Health and Sport. 2017;7(2):721-731. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1146882

http://ojs.ukw.edu.pl/index.php/johs/article/view/5209

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© The Author (s) 2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.02.2017. Revised 24.02.2017. Accepted: 27.02.2017.

UDC 615.31+615.451 

the influence of adrenalin and pilocarpin oral GELS on rat PARODONTE state

V. M. Batig1, A. V. Borysenko2, A. P. Levitsky3

1Bukovina State Medical University, Chernovtsy

2National Medical University named after O. O. Bogomolets, Kyiv

3State Establishment «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine», Odessa

Abstract

Aim: To determine the influence of adrenalin and pilocarpin upon periodontal tissues.

Methods: The gels with adrenalin (0,36 mg/kg) and pilocarpin (2 mg/m) were applicated on oral mucosa everyday during 30 days. The activity of elastase, urease, lysozyme, catalase and contents of malonic dialdehide and hyaluronic acid were determined into gum. The activity of phosphates and contents of calcium and protein were determined into bone of parodonte. The degree of dysbiosis were calculated by ration activities of urease and lysozyme. The mineralisation index were calculated by ration activities of alkaline and acid phosphatases. The degree of bone mineralisation was determined by ration contents of alcium and protein.

Results: The activity of elastase, the content of MDA and the degree of dysbiosis were lowered in gum after adrenalin application. The degree of dysbiosis was lowered in gum after application of pilocarpin. The mineralisation index of bone was lowered after adrenalin application.

Conclusion: The adrenalin and pilocarpin make periodontoprotective effect.

Keywords: periodonte, adrenalin, pilocarpin, inflammation, dysbiosis, bone mineralisation.