Effect of Chinese Green Tea on Glumerular Filtration Function of Albino Rats Treated with Gentamicin
Description
Abstract— Acute kidney injury (AKI) results from reduction in glumerular filtration rate (GFR) causing the passage of little or no urine. This study investigated the effects of Chinese green tea on glumerular filtrate functions of albino rats treated with gentamicin in view to evaluate its nephroprotective effect. Animals were procured from the animal house of Veterinary Medicine Department University of Nigeria Nsukka. The rats were transported to Biochemistry laboratory, acclimatize for 7 days and randomly assigned into five groups. The rats were fed with commercially prepared pellets (vital feed) and watered ad libitum throughout the duration of the study. Nephrotocity was induced with gentamicin at 80mg/kg for 7 consecutive days with co-administration of camellia sinensis extract. Blood samples were drawn from rats in each groups and were analyzed for biochemical parameters. Results obtained are; from urea (13.08-6.12mg/dl), creatinine (70.08-42.25mg/dl), cystatin C (0.084-0.027mg/dl) and GFR (2.20-1.30ml/mins). Findings reveal that Gentamicin induces nephrotoxicity through induction of oxidative stress and generation of Reactive Oxygen species (ROS). Nephrotoxicity is an acute kidney injury marked by induced GFR and serum accumulation of urea, creatinine and cystatin C. Camellia sinensis contains powerful antioxidants catechins which counters the oxidant effect of gentamicin, thereby ameliorating its nephrotoxicity. Therefore crude extract of Camellia sinnesis has nephro-protective effect and ability to maintain a relatively normal GFR.
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IJOER-MAY-2024-4.pdf
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