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Published June 3, 2024 | Version v1
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MOVARSim presets

Description

This page contains cancer-specific presets derived from COSMIC and TCGA to inform MOVARSim's parameters for 21 cancer types.

The presets contain the information needed to derive realistic and cancer-specific values for the characteristics of variants (total number of variants per sample, number of variants per type, variants zigosity, variants lengths, variants positions) which are specified in the main input format of MOVARSim, i.e. the VAR file. 

Files are named using the following format: <database_name>_mutations_workspace_<tumor_type>.RData.

- <database_name> can be either "cosmic_core" or "tgca".

- <tumor_type> can be: "adrenal_gland", "biliary_tract","bone", "cervix", "eye", "kidney", "liver", "esophagus", "ovary", "pancreas", "pleura", "prostate", "skin", "soft_tissue", "stomach", "testis", "thymus", "thyroid".

 

Files

Files (461.2 MB)

Name Size Download all
md5:583f462d7b0655003e4f7b21dbd4c4bc
198.9 kB Download
md5:0ee3b880018002897d1e9716eea07e96
13.9 MB Download
md5:a4269fa12d61c1860cc67be87734355a
1.2 MB Download
md5:e48451f6b745ffb85b173466db77163b
39.5 MB Download
md5:9e07c6ffa6ff703c41b5c5f46a8ef1dd
2.7 MB Download
md5:0c163e01fbb2459610a8842c6893b3b5
44.7 MB Download
md5:0de4726279dd64031151ccb8df0825bb
26.1 MB Download
md5:2f03de9fe400d2d55e58088410d3de3c
57.0 kB Download
md5:661e7076cdc08af0ef2b42a13ef7c43d
9.8 MB Download
md5:4bdb9772207b4251073fb32ac59b4196
60.7 MB Download
md5:c6e7461e9c1ad8e82b49cdafbcedbb57
32.0 MB Download
md5:6f009f4b2fbc0a34f85ad5eeb6a33bf5
13.9 MB Download
md5:a3cc6bded23cb0d94997dda693394942
33.8 MB Download
md5:413533ecfee8c5f1f252735713a24137
59.6 kB Download
md5:e754d8abf91a04230fe7f95dff17d1bd
28.0 MB Download
md5:eb9174da3fcb8d4bddf899b5fa933103
52.3 MB Download
md5:77030cddbf968209ff4ae51bde6ef9a9
10.1 MB Download
md5:3d9637cb4de54688b5c83d5cda314ace
26.0 MB Download
md5:b05a0598f3d1549049da61160eef5b42
51.4 kB Download
md5:99556dfdf45701ab26a4662e9e2dbbbb
27.7 kB Download
md5:8f0b91df4129912b72d965fd750c6d9b
5.3 MB Download
md5:701788e19ad38d64c11b943a2d4bce65
342.6 kB Download
md5:eff4c0875aa7e10d4edd79e72315ad62
24.8 kB Download
md5:15fd45fe1ec7c8c33fc69294ea5f7219
56.9 kB Download
md5:27686ccad15e371f76e1bf23995e1a50
3.4 MB Download
md5:819323d498f05fec87586c5bf41bba20
2.3 MB Download
md5:9e1d9e41c95b84f437ca43725c21467d
11.2 MB Download
md5:912c5e8f659655b1d84fb73b7211ac47
1.1 MB Download
md5:730cd1fac38bf0dfa4846b5cdcbc9ce0
24.7 kB Download
md5:4a7d53b162255ad9f90103ce5b43f179
1.9 MB Download
md5:6b13926c4ab2da5743e57c3178596578
1.5 MB Download
md5:b28cfb7e8b71979728bebf2184408354
15.7 MB Download
md5:ba982a3bf9f3ab86d6a2ae4750e8a44c
1.9 MB Download
md5:a79689334908a22ce31072609a9b7d4b
1.2 MB Download
md5:6c1825f259c25cad5759a57a91028cc2
45.5 kB Download
md5:87509ee59a868c4ab9f5b42ea626072b
732.0 kB Download
md5:1e12cabf7e5266fc236b266d0ec31af2
12.5 MB Download
md5:c0c9f24127bcf4e222acb3c7913a01c3
383.6 kB Download
md5:48f110b4ded306ce4a9cca311cd9b862
6.3 MB Download
md5:1aea56f811ca20210049bbced023d656
33.8 kB Download
md5:c405023105c83c2f91393466c6f184f2
31.7 kB Download
md5:079433d3a430bbb4f5c08cc748e6b774
59.9 kB Download

Additional details

Software

Repository URL
https://gitlab.com/sysbiobig/movarsim
Programming language
Python , R , C

References

  • Tate JG, Bamford S, Jubb HC, Sondka Z, Beare DM, Bindal N, Boutselakis H, Cole CG, Creatore C, Dawson E, Fish P, Harsha B, Hathaway C, Jupe SC, Kok CY, Noble K, Ponting L, Ramshaw CC, Rye CE, Speedy HE, Stefancsik R, Thompson SL, Wang S, Ward S, Campbell PJ, Forbes SA. COSMIC: the Catalogue Of Somatic Mutations In Cancer. Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947. doi: 10.1093/nar/gky1015. PMID: 30371878; PMCID: PMC6323903.
  • Cancer Genome Atlas Research Network; Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct;45(10):1113-20. doi: 10.1038/ng.2764. PMID: 24071849; PMCID: PMC3919969.