The Effect of Perinatal GBS Screening and IAP on Maternal and Infant Prognosis

Abstract—

Objective: To investigate the effect of perinatal Group B Streptococcus (GBS) infection and intrapartum antibiotic prophylaxis (IAP) regimen on maternal and infant clinical outcome.

Methods: From January to December 2023, 626 GBS-positive and 2565 GBS-negative, gestation 35-37 weeks pregnant women were included in the observation and the control groups respectively. We compared the outcomes of the maternal and infant between the two groups.

Results: The preterm birth rate and postpartum hemorrhage rate in the observation group were significantly lower than that in the control group. However the incidence of preterm rupture of membranes, the incidence for "placenta pathological examination" critically evaluated by "after- However the incidence of preterm rupture of membranes, the incidence for "placenta pathological examination" critically evaluated by "after- delivery check protocol" and neonatal clinical sepsis in the observation group was significantly higher than that of the control group. There was no statistically significant difference in terms of delivery methods, the incidence of macrosomia, the incidence of neonatal 1'Apgar score. There was no statistically significant difference in terms of delivery methods, the incidence of macrosomia, the incidence of neonatal 1'Apgar score ≤7 and neonatal pneumonia between the two groups.

Conclusions: The standardized maternal GBS screening and intrapartum antibiotic prophylaxis (IAP) programme adopted at our hospital was effective in reducing adverse maternal and neonatal outcomes.