Clinical Profile and Outcome of Organophosphorus Poisoning at Tertiary Care Hospital in Muzaffarpur, Bihar
Authors/Creators
- 1. Senior Resident, Department of General Medicine, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar
- 2. Assistant Professor, Department of General Medicine, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar
Description
Background: In the developing world, acute organophosphorus (OP) pesticide poisoning is common. Since the nation is mostly an agricultural one, pesticides and insecticides are widely employed in agriculture, and the general public has easy access to these hazardous chemicals. The objective of the study was to identify the nature of the demographic profile, type of compound, clinical manifestations, and outcome of organophosphate poisoning presenting to a tertiary care hospital in Muzaffarpur, Bihar. Methods: Between June 2023 and November 2023, a cross-sectional study including 100 patients diagnosed with OPC poisoning at Sri Krishna Medical College and Hospital Muzaffarpur, Bihar, was carried out in the general medicine department. The diagnosis of OP poisoning was established on the basis of the patient’s medical history or any evidence of exposure to the OP chemical within a 24-hour period. Symptoms such as fasciculations, miosis, excessive salivation, and improved signs and symptoms after atropine treatment were noted. IBM SPSS version 22 was used for statistical analysis. Results: Eighty percent of the subjects were male. The bulk (66%) belonged to the 21–40 year old age range. Methyl parathion was the most often ingested OPC (27%) and was followed by chlorpyrifos (22%). Abdominal pain/cramps accounted for 100% of the significant GIT problems, with nausea and vomiting coming in second with 83%. In 40% of the individuals, mechanical ventilation was required, and 25% of the subjects had reported death. Conclusion: Males in their economically productive stages of life are disproportionately affected by OP poisoning. Given the high death rate, it is imperative that health services be adequately strengthened, particularly at the primary level.
Abstract (English)
Background: In the developing world, acute organophosphorus (OP) pesticide poisoning is common. Since the nation is mostly an agricultural one, pesticides and insecticides are widely employed in agriculture, and the general public has easy access to these hazardous chemicals. The objective of the study was to identify the nature of the demographic profile, type of compound, clinical manifestations, and outcome of organophosphate poisoning presenting to a tertiary care hospital in Muzaffarpur, Bihar. Methods: Between June 2023 and November 2023, a cross-sectional study including 100 patients diagnosed with OPC poisoning at Sri Krishna Medical College and Hospital Muzaffarpur, Bihar, was carried out in the general medicine department. The diagnosis of OP poisoning was established on the basis of the patient’s medical history or any evidence of exposure to the OP chemical within a 24-hour period. Symptoms such as fasciculations, miosis, excessive salivation, and improved signs and symptoms after atropine treatment were noted. IBM SPSS version 22 was used for statistical analysis. Results: Eighty percent of the subjects were male. The bulk (66%) belonged to the 21–40 year old age range. Methyl parathion was the most often ingested OPC (27%) and was followed by chlorpyrifos (22%). Abdominal pain/cramps accounted for 100% of the significant GIT problems, with nausea and vomiting coming in second with 83%. In 40% of the individuals, mechanical ventilation was required, and 25% of the subjects had reported death. Conclusion: Males in their economically productive stages of life are disproportionately affected by OP poisoning. Given the high death rate, it is imperative that health services be adequately strengthened, particularly at the primary level.
Files
IJPCR,Vol16,Issue5,Article183.pdf
Files
(328.8 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:ee4da8b47a9ec3d42b8b76de51fe354f
|
328.8 kB | Preview Download |
Additional details
Dates
- Accepted
-
2024-04-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article183.pdf
- Development Status
- Active
References
- 1. Unnikrishnan B, Singh B, Rajeev A. Trends of acute poisoning in south Karnataka. Kathmandu Univ Med J. 2005;3(2)149-154. 2. Behere PB, Behere AP. Farmers' suicide in Vidarbha region of Maharashtra state- A myth or reality? Indian J Psychiatry. 2008;50(2)124- 27. 3. Zawar S. Correlation between plasma cholinesterase levels and clinical severity of acuteorganophosphate and carbamate poisoning. JAPI. 2001;149;91. 4. Aygun D, Doganay Z, Altintop L, Guven H, Onar M, Deniz T, et al. Serum acetylcholinesterase and prognosis of acute organophosphate poisoning. J Toxicol Clin Toxicol. 2002; 40(7): 903-910. 5. Banerjee I, Tripathi S, Roy AS. Clinicoepidemiological characteristics of patients presenting with organophosphorus poisoning. N Am J Med Sci. 2012;4(3)147-150. 6. Cherian M, Roshini C, Visalakshi J, Jeyaseelan L, Cherian A. Biochemical and clinical profile after organophosphorus poisoning A placebocontrolled trial using pralidoxime. J Assoc Physicians India. 2005;53;427-431. 7. Banday TH, Tathineni B, Desai MS, Naik V. Predictors of Morbidity and Mortality in Organophosphorus Poisoning- A Case Study in Rural Hospital in Karnataka, India. N Am J Med Sci. 2015;7(6)259-265. 8. Khan S, Kumar S, Agrawal S, Bawankule S. Correlation of serum cholinesterase and serum creatine phosphokinase enzymes with the severity and outcome of acute organophosphorus poisoning- study in rural central India. World J Pharmacy Pharmac Sci. 2016;5(4)1365-1373. 9. Chintale KN, Patne SV, Chavan SS. Clinical profile of organophosphorus poisoning patients at rural tertiary health care centre. Int J Adv Med. 2016;3(2)268-274. 10. Noshad H, Ansarin K, Ardalan MR, Ghaffari AR, Safa J, Nezami N. Respiratory failure in organophosphate insecticide poisoning. Saudi Med J. 2007;28(3)405-407. 11. Singhal A, Yang M, Sargent M, Cochrane D. Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus? Child's Nerv Syst. 2012; 29(2): 269-279. 12. Rao GV, Jyothsna M. Relation between Serum Cholinesterase and Mortality among Patients with OP Poisoning. Indian J ClinAnaesth. 2016;3(1)48-51. 13. Sungur M, Guven M. Intensive care management of organophosphate insecticide poisoning. Crit Care. 2001;5(4)211-215. 14. Shah SM, Asari PD, Amin AJ. Clinicoepidemiological profile of patients presenting with acute poisoning. Int J Curr Res Rev. 2016; 8(13):35-41.