Correlation between Systemic Biomarkers and Retinal Vein Occlusion: A Case Controlled Study
Creators
- 1. Assistant Professor, Department of Ophthalmology, Chhindwara Institute of Medical Sciences, Chhindwara, MP, India
- 2. Senior Resident, Department of Ophthalmology, Chhindwara Institute of Medical Sciences, Chhindwara, MP, India
- 3. Associate Consultant, Centre for Sight Eye Institute, New Delhi, India
Description
Background and Objectives: Retinal Vein occlusion (RVO) is the second most prevalent retinal vascular condition, occurring after diabetic retinopathy. It leads to painless vision impairment. RVO can be caused by a combination of several systemic, local, and hematologic illnesses. Recent studies have shown that certain inflammatory biomarkers and hyperlipidemia are more commonly linked to RVO. The objective of our investigation is to establish the correlation between systemic biomarkers and RVO. This correlation can assist patients with retinal vein occlusion (RVO) in recognizing other systemic diseases and in averting the occurrence of RVO in their other eyes. Material and Methods: In this retrospective study, a total of 50 patients were recruited from the Department of Ophthalmology, S.S. Medical College and affiliated Gandhi Memorial Hospital, Rewa (M.P.). The investigation was conducted after obtaining approval from the institutional ethics committee and obtaining informed written consent from the patients. Data collection involved obtaining a thorough medical history. Additionally, all participants in the research underwent a full eye examination. Laboratory tests were conducted to measure levels of inflammatory markers (CRP, Homocysteine) and lipid profile parameters (Cholesterol, Triglyceride, VLDL, LDL, HDL levels, MHR). The statistical analysis was conducted using SPSS version 24. The data was reported using the mean and standard deviation, or proportions when applicable. Results: The demographic characteristics of the two groups were similar. The average CRP and Homocysteine levels were considerably elevated in the patients compared to the controls. The lipid profile parameters, with the exception of HDL, exhibited considerable increases in individuals with RVOs. Conclusion: The present study demonstrates a correlation between retinal vein occlusion (RVO) and the inflammatory markers C-reactive protein (CRP) and homocysteine. These indicators might be considered as risk factors in the development of RVO. The present investigation has determined that it is necessary to assess the blood cholesterol levels of all patients who have experienced retinal vascular obstruction. It is uncertain if restoring normal levels of lipids in the blood may improve vision and prevent the occurrence of retinal vein occlusion (RVO) in the other eye, or if it can reduce complications and the recurrence of RVO in the same eye.
Abstract (English)
Background and Objectives: Retinal Vein occlusion (RVO) is the second most prevalent retinal vascular condition, occurring after diabetic retinopathy. It leads to painless vision impairment. RVO can be caused by a combination of several systemic, local, and hematologic illnesses. Recent studies have shown that certain inflammatory biomarkers and hyperlipidemia are more commonly linked to RVO. The objective of our investigation is to establish the correlation between systemic biomarkers and RVO. This correlation can assist patients with retinal vein occlusion (RVO) in recognizing other systemic diseases and in averting the occurrence of RVO in their other eyes. Material and Methods: In this retrospective study, a total of 50 patients were recruited from the Department of Ophthalmology, S.S. Medical College and affiliated Gandhi Memorial Hospital, Rewa (M.P.). The investigation was conducted after obtaining approval from the institutional ethics committee and obtaining informed written consent from the patients. Data collection involved obtaining a thorough medical history. Additionally, all participants in the research underwent a full eye examination. Laboratory tests were conducted to measure levels of inflammatory markers (CRP, Homocysteine) and lipid profile parameters (Cholesterol, Triglyceride, VLDL, LDL, HDL levels, MHR). The statistical analysis was conducted using SPSS version 24. The data was reported using the mean and standard deviation, or proportions when applicable. Results: The demographic characteristics of the two groups were similar. The average CRP and Homocysteine levels were considerably elevated in the patients compared to the controls. The lipid profile parameters, with the exception of HDL, exhibited considerable increases in individuals with RVOs. Conclusion: The present study demonstrates a correlation between retinal vein occlusion (RVO) and the inflammatory markers C-reactive protein (CRP) and homocysteine. These indicators might be considered as risk factors in the development of RVO. The present investigation has determined that it is necessary to assess the blood cholesterol levels of all patients who have experienced retinal vascular obstruction. It is uncertain if restoring normal levels of lipids in the blood may improve vision and prevent the occurrence of retinal vein occlusion (RVO) in the other eye, or if it can reduce complications and the recurrence of RVO in the same eye.
Files
IJPCR,Vol16,Issue5,Article139.pdf
Files
(2.4 MB)
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Additional details
Dates
- Accepted
-
2024-04-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue5,Article139.pdf
- Development Status
- Active
References
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