Institut za onkologiju i radiologiju Srbije / Institute for Oncology and Radiology of Serbia
Published December 15, 2023 | Version v.1
Journal article Restricted

Phytochemical composition, biological activity and anti-inflammatory potential of acetone extract from the lichen Platismatia glauca (L.) W.L. Culb. & C.F. Culb

Authors/Creators

  • 1. Department of Biology, Faculty of Science, University of Kragujevac, Kragujevac, Serbia
  • 2. Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
  • 3. Faculty of Science, University of Niš, Niš, Serbia
  • 4. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  • 5. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia
  • 6. Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, Kragujevac, Serbia
  • 7. ROR icon Institut des Maladies Métaboliques et Cardiovasculaires
  • 8. Department of Human Pathology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Description

Abstract

This investigation examined the antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities of the acetone extract of the lichen Platismatia glauca (L.) W.L. Culb. & C.F. Culb. (PGAE). The phytochemical study of PGAE showed presence of seven compounds: salazinic acid, β-orcinol carboxylic acid, 3-hydroxyphysodalic acid, physodalic acid, physodic acid, atranorin, and chloroatranorin. The antimicrobial potential was determined by microdilution which showed that S. aureus was most sensitive to the effect of PGAE with MIC value 0.312 mg/ml. Antioxidant activity was evaluated by using DPPH method. The obtained IC50 value for PGAE was 194.30 ± 3.32 µg/ml. The cytotoxic effect of the extract was evaluated by MTT test and the strongest activity was towards human epithelial carcinoma cells with IC50 value of 59.10 ± 0.46 µg/ml. The findings revealed that the application of lichen extracts decreased the paw edoema in a dose-dependent manner at 1, 2, 3, and 4 h following carrageenan administration.

Notes (English)

This study was funded by the Ministry of Education, Science and Technology Development of the Republic of Serbia (Agreement No 451-03-68/2022-14/200122, 451-03-47/2023-01/200111) and the Science Fund of the Republic of Serbia, The Program Ideas, project NES:7743504

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Additional details

Identifiers

ISSN
1478-6419
PMID
38099357
URL
https://www.tandfonline.com/doi/full/10.1080/14786419.2023.2294479

Dates

Accepted
2023-12-06
Available
2023-12-15

Software

Repository URL
https://zenodo.org/uploads/11402595
Development Status
Active