THE IMPORTANCE OF DIFFERENTIAL DIAGNOSING IN TREATMENT OF MARGINAL BLEPHARITIS WITH DEMODEX ETIOLOGY

Human Demodex mites play a significant role in the skin microbiome's evolutionary hierarchy, with their presence typically being harmless. However, human demodicosis, a unique skin disease, can resemble various inflammatory skin conditions, leading to confusion in medical literature. The proposal suggests categorizing demodicosis into primary and secondary forms, with primary demodicosis manifesting in different ways, such as spinulate demodicosis, papulopustular/nodulocystic demodicosis, ocular demodicosis, and auricular demodicosis. Secondary demodicosis is often linked to immunosuppression. Treatment approaches lack strong evidence, and the optimal acaricide concentrations are yet to be determined. Enhancing in vitro or ex vivo culture models is crucial for future research. The potential role of bacterial endosymbiosis with Demodex mites in demodicosis pathogenesis requires further investigation through clinical studies and experiments to validate the hypothesis.