Deficient Ovarian Reserve in Genital Tuberculosis
- 1. Assistant Professor, Department of Obstetrics and Gynaecology, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar
- 2. Professor and Head of Department, Department of Obstetrics and Gynaecology, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar
Description
Objective: To assess ovarian reserve (OR) in infertile women with GTB and compare with women with proven fertility by Hormonal and Ultrasound markers of ovarian reserve. Methods: A cross-sectional study was conducted at an outpatient DMCH, DARBHANGA, India with 50 women with Gestational Tuberculosis (GTB) and 50 healthy controls. Ovarian reserve tests were done by estimating serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), on day 3 of a natural menstrual cycle and anti-Mullerian hormone (AMH) in any day of cycle. On D3 Antral Follicles Count (AFC) were also estimated on Ultrasound. Result: The median FSH was 8.91 (5.60-11.07) mIU/ml, LH 6 (4.65-8.55) mIU/ml and the mean E2 61.30±15.23 pg/ml which were significantly higher than controls (FSH-5.50, LH-3.80, and E2-41.53). The median AMH levels 1.23 ng/ml was significantly lower in GTB than controls (AMH-2.50). And, the median AFC 6.0(4.0-8.0) was significantly lower in GTB than control 11.0 (8.25-12.0). Conclusion: The median FSH, LH and the mean E2 on day-3 of cycle and AMH on any day of cycle along with AFC are good predictors of Ovarian reserve and found to be low in GTB.
Abstract (English)
Objective: To assess ovarian reserve (OR) in infertile women with GTB and compare with women with proven fertility by Hormonal and Ultrasound markers of ovarian reserve. Methods: A cross-sectional study was conducted at an outpatient DMCH, DARBHANGA, India with 50 women with Gestational Tuberculosis (GTB) and 50 healthy controls. Ovarian reserve tests were done by estimating serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), on day 3 of a natural menstrual cycle and anti-Mullerian hormone (AMH) in any day of cycle. On D3 Antral Follicles Count (AFC) were also estimated on Ultrasound. Result: The median FSH was 8.91 (5.60-11.07) mIU/ml, LH 6 (4.65-8.55) mIU/ml and the mean E2 61.30±15.23 pg/ml which were significantly higher than controls (FSH-5.50, LH-3.80, and E2-41.53). The median AMH levels 1.23 ng/ml was significantly lower in GTB than controls (AMH-2.50). And, the median AFC 6.0(4.0-8.0) was significantly lower in GTB than control 11.0 (8.25-12.0). Conclusion: The median FSH, LH and the mean E2 on day-3 of cycle and AMH on any day of cycle along with AFC are good predictors of Ovarian reserve and found to be low in GTB.
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IJPCR,Vol15,Issue9,Article249.pdf
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Additional details
Dates
- Accepted
-
2023-08-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue9,Article249.pdf
- Development Status
- Active
References
- 1. Broekmans F J, Knauff E A, te Velde E R, et al. Female reproductive ageing: Current knowledge and future trends. Trends Endocrinol Metab, 2007, 18: 58–65. 2. te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update 2002: 8; 141-54. 3. Hunt P A, Hassold T J. Human female meiosis: What makes a good egg go bad? Trends Genet, 2008, 24: 86–93. 4. Warburton D. Biological aging and the etiology of aneuploidy. Cyto genet Genome Res, 2005, 111: 266–272. 5. Schaefer G. Female genital tuberculosis. Clin Obstet Gynecol 1976; 19(1):223–39. 6. Tripathy SN. Infertility and pregnancy outcome in female genital tuberculosis. Int J Gynecol Obstet 2002; 76(2):159–63. 7. Malhotra N, Sharma V, Bahadur A, Sharma J B. et al. / The effect of tuberculosis on ovarian reserve among women undergoing IVF in India. International Journal of Gynecology and Obstetrics 117 (2012) 40–44. 8. Anupama Bahadur, Neena Malhotra, Neeta Singh, Mani Kalaivani, Suneeta Mittal. Role of perifollicular Doppler blood flow in predicting cycle response in infertile women with genital tuberculosis undergoing in vitro fertilization/ intracytoplasmic sperm injection. Journal of Human Reproductive Sciences.2014; 7(1):19-24. 9. Gnoth C, Schuring AN, Friol K, Tigges J, Mallmann P, Godehardt E. Relevance of antiMüllerian hormone measurement in a routine IVF program. Hum Reprod2008; 23:1359–65. 10. Ebner T, SommergruberM,MoserM, Shebl O, Schreier-Lechner E, Tews G. Basal level of anti-Müllerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 2006; 21 (8):2022–2026. 11. Tremellen KP, Kolo M, Gilmore A, Lekamge DN. Anti-Müllerian hormone as a marker of ovarian reserve. Aust N Z J Obstet Gynaecol2005; 45:20–4.