SYNTHESIS OF 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS POTENTIAL AS ANTIMICROBIAL AGENTS BY USING MICROWAVE IRRADIATION METHOD

The main aim of the project is 2-substituted benzimidazole derivatives were prepared by the microwave induced reaction between O-Phenylene diamine and various aromatic aldehydes and aromatic acids. The synthesized compounds have been characterized and confirmed by TLC, elemental analysis, FTIR spectroscopy and screened for their antibacterial activity. • Prepared by the reaction of  orthophenylene diamine  with equivalent of  aromatic acid and  dilute 4N HCl. The mixture was refluxed with condenser in synthetic microwave oven at 100° Watts for 5-10 minutes. The mixture was cooled and added 10% NaOH solution till the reaction mixture was neutralized. Then the mixture was separated by vaccum evaporation techinque, dried and calculate the percentage yield. Find out the melting point range and characterize the products using thin layer chromatography, FTIR spectroscopy to confirmm its purity. All the synthesied compounds was screened for invitro antimicrobial activity. the current research shows a rapid, clean, and environmentally sustainable method of the microwave-assisted synthesis of 2-substituted benzimidazoles. The proposed method reduces the reaction time and energy consumption, making developing the process industrially appropriate. The synthesized compounds were recrystallized from ethanol and characterized by thin layer chromatography (TLC), Melting point, FT-IR studies. The synthesized compounds were screened for antimicrobial activity.

Key words: Synthesis, Biological Evaluation, 2-Substituted Benzimidazole Derivatives, FT IR, TLC