Prospective Observational Study on the Management of Amoebic and Pyogenic Liver Abscess
Authors/Creators
- 1. Senior Resident, Department of General Surgery, IGIMS, Patna
- 2. MD, Medicine, Specialist Medical Officer, SDH Banmankhi, Purnia
- 3. Additional Professor, Department of General Surgery, IGIMS, Patna
Description
Background: Liver abscesses, whether caused by amoeba or pyogenic, can be pretty dangerous. The best possible outcomes for patients depend on rapid and correct diagnosis and treatment. Methods: We analysed 150 patients diagnosed with liver abscesses between January 1, 2022, and December 31, 2022, using a prospective observational study design. Patients’ demographics, clinical presentation, diagnostic procedures, treatment options, and outcomes were recorded. Associations were found, and statistical tests evaluated treatment efficacy. Results: 150 individuals with either pyogenic or amoebic abscesses were included in the study. Clinical manifestations varied between amoebic and pyogenic abscesses, with fever being more common in the former (83.7%). Abdominal pain was more common in the latter (91.2%), jaundice was less common in the former (12.0% vs 24.0%, p = 0.049), and other symptoms were more common in the latter (32.0%). Ultrasound (sensitivity 89.3%, specificity 91.7%), CT scan (sensitivity 92.0%, specificity 88.7%), blood cultures (sensitivity 78.7%, specificity 94.5%), and serological tests (sensitivity 95.3%, specificity 82.4%) were all highly accurate at distinguishing between the two aetiologies. High success rates were seen with antibiotic therapy for both groups (98.7% vs 96.0%, p = 0.143), whereas pyogenic abscesses fared better with percutaneous drainage (62.7% vs 75.3%, p = 0.032). Conclusion: As demonstrated by our research, the key to effectively managing liver abscesses is a combination of accurate diagnosis and all-encompassing treatment. Accurate diagnostics, effective treatments, and statistically meaningful findings improve clinical decision-making and patient outcomes.
Abstract (English)
Background: Liver abscesses, whether caused by amoeba or pyogenic, can be pretty dangerous. The best possible outcomes for patients depend on rapid and correct diagnosis and treatment. Methods: We analysed 150 patients diagnosed with liver abscesses between January 1, 2022, and December 31, 2022, using a prospective observational study design. Patients’ demographics, clinical presentation, diagnostic procedures, treatment options, and outcomes were recorded. Associations were found, and statistical tests evaluated treatment efficacy. Results: 150 individuals with either pyogenic or amoebic abscesses were included in the study. Clinical manifestations varied between amoebic and pyogenic abscesses, with fever being more common in the former (83.7%). Abdominal pain was more common in the latter (91.2%), jaundice was less common in the former (12.0% vs 24.0%, p = 0.049), and other symptoms were more common in the latter (32.0%). Ultrasound (sensitivity 89.3%, specificity 91.7%), CT scan (sensitivity 92.0%, specificity 88.7%), blood cultures (sensitivity 78.7%, specificity 94.5%), and serological tests (sensitivity 95.3%, specificity 82.4%) were all highly accurate at distinguishing between the two aetiologies. High success rates were seen with antibiotic therapy for both groups (98.7% vs 96.0%, p = 0.143), whereas pyogenic abscesses fared better with percutaneous drainage (62.7% vs 75.3%, p = 0.032). Conclusion: As demonstrated by our research, the key to effectively managing liver abscesses is a combination of accurate diagnosis and all-encompassing treatment. Accurate diagnostics, effective treatments, and statistically meaningful findings improve clinical decision-making and patient outcomes.
Files
IJPCR,Vol15,Issue9,Article115.pdf
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Additional details
Dates
- Accepted
-
2023-08-29
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue9,Article115.pdf
- Development Status
- Active
References
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