Efficacy of Palonosetron and Dexamethasone for Prevention of PostOperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholycystectomy
Authors/Creators
- 1. Senior Resident, Department of Anaesthesia, Ananta Institute of Medical Sciences and Research Centre, Siyol, Rajasthan
- 2. Assistant Professor, Department of Anaesthesia, Narendra Modi Medical College, Maninagar, Ahmadabad, Gujarat
- 3. Third Year Resident, Department of Anaesthesia, Narendra Modi Medical College, Maninagar, Ahmadabad, Gujarat
Description
Background and Aim: PONV (postoperative nausea and vomiting) is a very uncomfortable and unpleasant symptom. Dexamethasone and palonosetron are antiemetic medications with few side effects. The current study was conducted with the goal of determining whether the combination of palonosetron and dexamethasone would be more effective as an antiemetic for PONV prophylaxis than either drug alone, and the study was designed to accept or reject that hypothesis. Material and Methods: A double-blind, randomised interventional research was planned. The study involved 300 patients who met the inclusion criteria (age: 18-60 years, American Society of Anesthesiologists (ASA) physical status I and II, undergoing laparoscopic cholecystectomy under general anaesthetic). They were divided into three groups and assigned to one of three treatment regimens: (n = 100) in Group A Group B (n = 100) received Dexamethasone 8 mg plus Palonosetron 0.075 mg. Palonosetron 0.075 mg on its own OR Group C (n = 100) Dexamethasone 8 mg on its own. The primary outcome was the occurrence of PONV within 24 hours, while the secondary result was the number of rescue antiemetic medications required. To compare the means of the three groups, the one-way ANOVA test was performed. Results: The overall occurrences of PONV in the study 24 h postoperatively were 20% in group A, 40% in group B, and 82% in group C (P 0.001). The dexamethasone group required more rescue antiemetic than the other two groups. Conclusion: Palonosetron and palonosetron-dexamethasone combinations were more effective than dexamethasone alone in avoiding PONV in patients undergoing laparoscopic cholecystectomy.
Abstract (English)
Background and Aim: PONV (postoperative nausea and vomiting) is a very uncomfortable and unpleasant symptom. Dexamethasone and palonosetron are antiemetic medications with few side effects. The current study was conducted with the goal of determining whether the combination of palonosetron and dexamethasone would be more effective as an antiemetic for PONV prophylaxis than either drug alone, and the study was designed to accept or reject that hypothesis. Material and Methods: A double-blind, randomised interventional research was planned. The study involved 300 patients who met the inclusion criteria (age: 18-60 years, American Society of Anesthesiologists (ASA) physical status I and II, undergoing laparoscopic cholecystectomy under general anaesthetic). They were divided into three groups and assigned to one of three treatment regimens: (n = 100) in Group A Group B (n = 100) received Dexamethasone 8 mg plus Palonosetron 0.075 mg. Palonosetron 0.075 mg on its own OR Group C (n = 100) Dexamethasone 8 mg on its own. The primary outcome was the occurrence of PONV within 24 hours, while the secondary result was the number of rescue antiemetic medications required. To compare the means of the three groups, the one-way ANOVA test was performed. Results: The overall occurrences of PONV in the study 24 h postoperatively were 20% in group A, 40% in group B, and 82% in group C (P 0.001). The dexamethasone group required more rescue antiemetic than the other two groups. Conclusion: Palonosetron and palonosetron-dexamethasone combinations were more effective than dexamethasone alone in avoiding PONV in patients undergoing laparoscopic cholecystectomy.
Files
IJPCR,Vol15,Issue9,Article63.pdf
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Additional details
Dates
- Accepted
-
2023-08-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue9,Article63.pdf
- Development Status
- Active
References
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