A Prospective Study on Expression of Human Leukocyte Antigen 1 in Cancer Cervix Patients
- 1. Assistant professor, Department of Pathology, Government Mohan Kumaramangalam Medical College, Salem
Description
Introduction: Cervix is the most common site in the female genital tract which is exposed to viral and bacterial infections. Also it is the target for carcinogenic agents leading to invasive cancer. The local tissue immune status may play a role in cancer cervix. Routine cytological PAP smear screening, early diagnosis and curative treatment had reduced the mortality of cancer cervix. The aim of our study is to examine the expression of HLA 1 in various types of carcinoma cervix and to correlate them according to their grades of malignancy. Methods: We chose the hysterectomy and small cervical biopsy tissues of cervical cancer and then detected the expression of HLA 1 using SP immunohistochemistry. The association of the HLA 1 expression with the clinicopathologic profiles of the patients was analyzed. Results: The positive staining of HLA class 1 antigen in well differentiated carcinoma is 7 out of 24 SCC cases and the negative staining of HLA class 1 in poorly differentiated form of SCC is 5 out of 24 cases. Conclusion: The expression of HLA 1 are down regulated in poorly differentiated carcinomas and it is more efficiently expressed in well differentiated forms which indicates that there is a good prognosis in well differentiated carcinomas because of HLA 1expression.
Abstract (English)
Introduction: Cervix is the most common site in the female genital tract which is exposed to viral and bacterial infections. Also it is the target for carcinogenic agents leading to invasive cancer. The local tissue immune status may play a role in cancer cervix. Routine cytological PAP smear screening, early diagnosis and curative treatment had reduced the mortality of cancer cervix. The aim of our study is to examine the expression of HLA 1 in various types of carcinoma cervix and to correlate them according to their grades of malignancy. Methods: We chose the hysterectomy and small cervical biopsy tissues of cervical cancer and then detected the expression of HLA 1 using SP immunohistochemistry. The association of the HLA 1 expression with the clinicopathologic profiles of the patients was analyzed. Results: The positive staining of HLA class 1 antigen in well differentiated carcinoma is 7 out of 24 SCC cases and the negative staining of HLA class 1 in poorly differentiated form of SCC is 5 out of 24 cases. Conclusion: The expression of HLA 1 are down regulated in poorly differentiated carcinomas and it is more efficiently expressed in well differentiated forms which indicates that there is a good prognosis in well differentiated carcinomas because of HLA 1expression.
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IJPCR,Vol15,Issue9,Article42.pdf
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Additional details
Dates
- Accepted
-
2023-08-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue9,Article42.pdf
- Development Status
- Active
References
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