Correlation of T3, T4 and TSH Levels with Diastolic Blood Pressure in Premenopausal Women with Altered Thyroid Hormone Status
Creators
- 1. Assistant Professor, Department of Physiology, Government Medical College, Osmanabad, Maharashtra, India
- 2. Ex Professor & Head of Department of Physiology, Rajarshee Chhatrapati Shahu Maharaj Government Medical College, Kolhapur, Maharashtra, India
- 3. Assistant Professor, Department of Pathology, Government Medical College, Aurangabad, Maharashtra, India
- 4. Associate Professor, Department of Physiology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, Maharashtra, India
Description
Introduction: Hypothyroid or Hyperthyroid state affects all the physiological systems including the cardiovascular system. Among all adverse changes, diastolic blood pressure can also be affected in patients with thyroid disorders. Objectives: The present study was carried out find out correlation of T3, T4 and TSH levels with diastolic blood pressure in premenopausal women with altered thyroid hormone status Materials and Methods: The present study was carried out in 90 female subjects in the age group of 30 to 45. Diagnosis of hypothyroidism and hyperthyroidism was based on both clinical and biochemical criteria. Subjects were divided in euthyroid, hypothyroid and hyperthyroid groups with each group containing 30 subjects. Resting diastolic blood pressure was measured in all the groups. Results: A negative linear correlation of total T3 and total T4 hormone level with resting diastolic blood pressure (p<0.001) was observed. A positive linear correlation of total TSH hormone level with resting diastolic blood pressure (p<0.001) was noted. Conclusion: Thyroid hormone directly or indirectly decreases peripheral resistance by dilating the arterioles. As T3 and T4 levels increase and as TSH levels decrease, resting diastolic blood pressure goes on decreasing linearly. On the other hand, as T3 and T4 levels decrease and as TSH levels increase, resting diastolic blood pressure goes on increasing linearly. Hence thyroid hormone concentration should be kept within normal limits by appropriate therapeutic measures so as to prevent ill effects of resultant deranged diastolic blood pressure.
Abstract (English)
Introduction: Hypothyroid or Hyperthyroid state affects all the physiological systems including the cardiovascular system. Among all adverse changes, diastolic blood pressure can also be affected in patients with thyroid disorders. Objectives: The present study was carried out find out correlation of T3, T4 and TSH levels with diastolic blood pressure in premenopausal women with altered thyroid hormone status Materials and Methods: The present study was carried out in 90 female subjects in the age group of 30 to 45. Diagnosis of hypothyroidism and hyperthyroidism was based on both clinical and biochemical criteria. Subjects were divided in euthyroid, hypothyroid and hyperthyroid groups with each group containing 30 subjects. Resting diastolic blood pressure was measured in all the groups. Results: A negative linear correlation of total T3 and total T4 hormone level with resting diastolic blood pressure (p<0.001) was observed. A positive linear correlation of total TSH hormone level with resting diastolic blood pressure (p<0.001) was noted. Conclusion: Thyroid hormone directly or indirectly decreases peripheral resistance by dilating the arterioles. As T3 and T4 levels increase and as TSH levels decrease, resting diastolic blood pressure goes on decreasing linearly. On the other hand, as T3 and T4 levels decrease and as TSH levels increase, resting diastolic blood pressure goes on increasing linearly. Hence thyroid hormone concentration should be kept within normal limits by appropriate therapeutic measures so as to prevent ill effects of resultant deranged diastolic blood pressure.
Files
IJPCR,Vol15,Issue9,Article2.pdf
Files
(354.4 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:6766cda33ed1b032c8b2aa12bbec09cf
|
354.4 kB | Preview Download |
Additional details
Dates
- Accepted
-
2023-08-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue9,Article2.pdf
- Development Status
- Active
References
- 1. Andersson M, Karumbunathan V, Zimmermann MB. Global iodine status in 2011 and trends over the past decade. J Nutr. 2012; 142(4): 744-50. 2. Pandav CS, Yadav K, Srivastava R, Pandav R, Karmarkar MG. Iodine deficiency disorders (IDD) control in India. Indian J Med Res 2013; 138(3): 418–433. 3. Bhat AN, Kalsotra L, Yograj S. Autonomic reactivity with altered thyroid status. JK Sci. 2007; 9(2): 70–4. 4. Ewing D.J, Clarke BF. Diagnosis and management of diabetic autonomic neuropathy. Br Med J. 1982; 285(6351): 1353. 5. Saito I, Ito K, Saruta T. Hypothyroidism as a Cause of Hypertension. Ahajournal. 1983; 5: 112-115. 6. Luboshitzky R, Aviv A, Herer P, Lavie L. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. 2002, 12(5): 421-425. 7. Stabouli S, Papakatsika S, Kotsis V. Hypothyroidism and Hypertension. Expert Rev Cardiovasc Ther. 2010; 8(11): 1559-1565. 8. Mahajan AS, Lal R, Dinesh K. Dhanwal, Jain AK, Chowdhury V. Evaluation of autonomic functions in subclinical hypothyroid and hypothyroid patients. Indian J Endocrinolo and Metab. 2013; 17(3): 460-64. 9. Klein I, Ojamaa K. Thyroid hormone and cardiovascular system. N Engl J Med. 2001; 344: 501-509. 10. Napoli R, Biondi B, Guardasole v. Impact of hyperthyroidism and its correlation on vascular reactivity in humans. Circulation. 2001; 104: 3076-3080.