Pulmonary Function and Hematological Characteristics in Children with Thalassemia Major
Authors/Creators
- 1. Tutor, Department of Physiology, JNKTMCH, Madhepura
- 2. Tutor, Department of Physiology, JLNMCH, Bhagalpur
- 3. HOD, Department of Physiology, DMCH, Lehariasarai, Darbhanga
Description
Background: Insufficient production of the haemoglobin chains causes persistent hemolytic anaemia in people with thalassemia, a series of recessively inherited illnesses. The exact source of pulmonary function problems after iron overload from repeated blood transfusions is unknown. Methods: The pulmonary function of transfusion-reliant children with thalassemia was evaluated and compared to that of typically developing children in this case-control study. For this study, 35 kids were selected at random. Serum ferritin levels were examined for their possible links to pulmonary dysfunction. Results: The study found that the ages at which thalassemia patients began receiving transfusion therapy ranged from 1.5 months to 70 months, with a median of 8 months. Haemoglobin levels before transfusion ranged from 6.8 to 11.4 gm%, on average hovering around 8.5 gm%. There was a wide range from 850 ml to 37,200 ml of blood transfused. The average serum ferritin concentration was 2000 ng/ml last year. Patients on chelation therapy for an average of 4.7 years. Although most pulmonary function test (PFT) measures were within normal ranges when comparing thalassemia cases and controls, PEF 25%-75% was considerably lower in thalassemia-affected children. Conclusion: This study reveals the prevalence of pulmonary dysfunction, especially in a restrictive lung pattern, in thalassemia patients, although these individuals may not exhibit clinical symptoms of pulmonary dysfunction. Multiple causes contribute to the disease’s development, including excessive blood transfusions, chelation therapy, and iron overload. More study is required to understand the causes and develop effective strategies for avoiding problems.
Abstract (English)
Background: Insufficient production of the haemoglobin chains causes persistent hemolytic anaemia in people with thalassemia, a series of recessively inherited illnesses. The exact source of pulmonary function problems after iron overload from repeated blood transfusions is unknown. Methods: The pulmonary function of transfusion-reliant children with thalassemia was evaluated and compared to that of typically developing children in this case-control study. For this study, 35 kids were selected at random. Serum ferritin levels were examined for their possible links to pulmonary dysfunction. Results: The study found that the ages at which thalassemia patients began receiving transfusion therapy ranged from 1.5 months to 70 months, with a median of 8 months. Haemoglobin levels before transfusion ranged from 6.8 to 11.4 gm%, on average hovering around 8.5 gm%. There was a wide range from 850 ml to 37,200 ml of blood transfused. The average serum ferritin concentration was 2000 ng/ml last year. Patients on chelation therapy for an average of 4.7 years. Although most pulmonary function test (PFT) measures were within normal ranges when comparing thalassemia cases and controls, PEF 25%-75% was considerably lower in thalassemia-affected children. Conclusion: This study reveals the prevalence of pulmonary dysfunction, especially in a restrictive lung pattern, in thalassemia patients, although these individuals may not exhibit clinical symptoms of pulmonary dysfunction. Multiple causes contribute to the disease’s development, including excessive blood transfusions, chelation therapy, and iron overload. More study is required to understand the causes and develop effective strategies for avoiding problems.
Files
IJPCR,Vol15,Issue10,Article12.pdf
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Additional details
Dates
- Accepted
-
2023-09-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue10,Article12.pdf
- Development Status
- Active
References
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