Prevalence of Undiagnosed Hypothyroidism in Gall Bladder Stones Patients
Creators
- 1. Assistant Professor, Department of General Surgery, Gujarat Adani Institute of Medical Science, India
Description
Background and Aim: The hypersaturation of cholesterol in bile during the nucleation process, a crucial stage in the formation of bile stones, has been the subject of numerous studies conducted in the west to uncover risk factors for biliary lithiasis. The prevalence of gall stones is higher in people with hypothyroidism condition, according to several reasons for a potential relationship between hypothyroidism and lipid metabolism and gall stone development. The current study aims to determine hypothyroidism as a likely cause of biliary stones in Tertiary care teaching institute of India by examining the prevalence of undiagnosed hypothyroidism in patients with cholelithiasis. Material and Methods: In a Tertiary Care Teaching Institute in India, a prospective, hospital-based cross-sectional study was conducted on patients hospitalised for the treatment of gall stone disease in the general surgery department over the course of a year. After initial screening, patients who met the selection criteria provided a thorough history, paying particular attention to symptomatology and risk factors as per the proforma. All patients who qualified had their thyroid function tested. Three groups of patients—euthyroid, subclinical hypothyroid, and clinical hypothyroidism—were created. used statistical analysis. The prevalence of hypothyroidism and subclinical hypothyroidism in all patients included was obtained after determining the percentage of gall stones in different age groups and genders of the study population. Results: Four of the 160 patients were under the age of 20, 48 were between the ages of 21 and 40, 40 were between the ages of 41 and 60, and 56 were between the ages of 61 and 80. Of of 160 patients, 112 had normal thyroid function, 40 had subclinical hypothyroidism, and 8 had hypothyroidism as their official diagnosis. The research population, which had an unknown thyroid function, displayed indications of hypothyroidism. Conclusion: The study showed a considerable frequency of hypothyroidism in cases of cholelithiasis of 29%. 6 percent had clinical hypothyroidism, while 23 percent had subclinical hypothyroidism. According to this study, ladies over 40 years old have a higher prevalence. The study group had hypothyroid symptoms while having unknown thyroid status, which strongly suggests thyroid profile testing prior to surgery.
Abstract (English)
Background and Aim: The hypersaturation of cholesterol in bile during the nucleation process, a crucial stage in the formation of bile stones, has been the subject of numerous studies conducted in the west to uncover risk factors for biliary lithiasis. The prevalence of gall stones is higher in people with hypothyroidism condition, according to several reasons for a potential relationship between hypothyroidism and lipid metabolism and gall stone development. The current study aims to determine hypothyroidism as a likely cause of biliary stones in Tertiary care teaching institute of India by examining the prevalence of undiagnosed hypothyroidism in patients with cholelithiasis. Material and Methods: In a Tertiary Care Teaching Institute in India, a prospective, hospital-based cross-sectional study was conducted on patients hospitalised for the treatment of gall stone disease in the general surgery department over the course of a year. After initial screening, patients who met the selection criteria provided a thorough history, paying particular attention to symptomatology and risk factors as per the proforma. All patients who qualified had their thyroid function tested. Three groups of patients—euthyroid, subclinical hypothyroid, and clinical hypothyroidism—were created. used statistical analysis. The prevalence of hypothyroidism and subclinical hypothyroidism in all patients included was obtained after determining the percentage of gall stones in different age groups and genders of the study population. Results: Four of the 160 patients were under the age of 20, 48 were between the ages of 21 and 40, 40 were between the ages of 41 and 60, and 56 were between the ages of 61 and 80. Of of 160 patients, 112 had normal thyroid function, 40 had subclinical hypothyroidism, and 8 had hypothyroidism as their official diagnosis. The research population, which had an unknown thyroid function, displayed indications of hypothyroidism. Conclusion: The study showed a considerable frequency of hypothyroidism in cases of cholelithiasis of 29%. 6 percent had clinical hypothyroidism, while 23 percent had subclinical hypothyroidism. According to this study, ladies over 40 years old have a higher prevalence. The study group had hypothyroid symptoms while having unknown thyroid status, which strongly suggests thyroid profile testing prior to surgery.
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Additional details
Dates
- Accepted
-
2021-10-01
Software
References
- 1. Pierre F Saldinger. Natural history of gall stones and asymptomatic gallstones. In: Jarnagin WR, Belghiti J, Blumgart LH eds. Blumgart's surgery of the liver, biliary tract, and pancreas. 6th ed. Philadelphia: Elsevier Saunders; 2012:483-583. 2. I.J. Beckingham, B.J. Rowlands, Post cholecystectomy problems, in: H. Blumgart (Ed.), Surgery of Liver and Biliary Tract, third ed., WB Saunders, London, 2000;186. 3. A. Nakeeb, A.G. Comuzzie, L. Martin, et al., Gall stones: genetics versus environment, Ann. Surg. 2002; 235:842 4. Norman S. Wiliam, Bassi chemical analysis of gallstones 2004 clinical biochemistry, 2; 1178 – 1188. 5. N, aggiol , Ghiro S,meggiato T, Di Mariof, Del Favero G,Scalon P,Molinm, Damico D,Naccarato R, 1990. X- ray diffraction study of biliary calculi Gelin Med, 71: 331–335. 6. Kleinero, Ramesh J,Huleihel M,Cohen Z,Mordechai S, 2002. Acomartive study of gallstone from children and adult using FTIR spectroscopy and flurorescence microscopy. BMC Gastroenterol, 2:3-15. 7. V. Fatourechi, Subclinical hypothyroidism: an update for primary care physicians, Mayo Clin. Proc. 2009; 84 (1): 65–71. 8. C. Menendez, R. Baldelli, J.P. Camina, et al., TSH stimulates leptin secretion by a direct effect on adipocytes, J. Endocrinol. 2003; 176: 7–12. 9. E. Abe, R.C. Marians, W. Yu, et al., TSH is a negative regulator of skeletal remodeling, Cell. 2003; 115: 151–162. 10. Laukkarinen J, Sand J, Aittomaki S, Porsti I, Koobi P, Kalliovalkama J, et al. Mechanism of the prorelaxing effect of thyroxine on the sphincter of Oddi. Scand J Gastroenterol. 2002;37(6):667-73. 11. Inkinen G,S & J,Norback I, 2001. Association between common bile duct stones and treated hypothyroidism, Hepatogastroenterology;47:919-921. 12. ] Mir Mujtaba Ahmad, Mir Irfan Nazirl, Haneef Mohamed Darl, et al., Evaluation of thyroid profile in biliary tract stones, International Surgery Journal. 2015;12(3): 344. 13. Laukkarinen J, Sand J, Saaristo R, Salmi J, Turjanmaa V, Vehkalahti P et al. Is bile flow reduced in patients with hypothyroidism? Surgery. 2003; 133(3): 288-93. 14. Laukkarinen J, Kiudelis G, Lempinen M, Räty S, Pelli H, Sand J et al. Increased prevalence of subclinical hypothyroidism in common bile duct stone patients. J Clin Endocrinol Metab. 2007;92(11):4260-4. 15. Laukkarinen J, Sand J, Autio V, Nordback I. Bile duct stone procedures are more frequent in patients with hypothyroidism. A large, registry-based, cohort study in Finland. Scand J Gastroenterol. 2010; 45(1): 70-4. 16. Singha D, Pawar NM, Prabhu BJ, Kumar N, Gopalarathnam S. Prevalence of previously undiagnosed hypothyroidism in patients with cholelithiasis in a tertiary care center, North-East India. Int Surg J. 2017; 4(3):932-5. 17. Watali YZ, Jain R, Bali RS, Mittal A. Is hypothyroidism a risk for gall stone disease? a study to assess the association. Int Surg J. 2017;4(8):2665-9. 18. Raghuwanshi BS, Jain S, Damor M, Patbamniya NK. Prevalence of subclinical hypothyroidism in cases of cholelithiasis. Int Surg J. 2017;5(1):34-8. 19. J. Laukkarinen, G. Kiudelis, M. Lempinen, et al., Increased prevalence of subclinical hypothyroidism, Metab. 2007; 92(11): 4260–4264. 20. Volzke Henry, Daniel M. Robinson, John Ulrich, et al., Association between thyroid function and gallstone disease, World J. Gastroenterol. 2005; 2(35).