EFFECTS OF INTERMITTENT FASTING ON METABOLISM IN INDIVIDUALS WITH TYPE II DIABETES MELLITUS

Background: For obese people, intermittent fasting (IF) has been suggested as a weight-loss method with extra cardiometabolic advantages. It's still unknown how IF affects people with type 2 diabetes (T2DM), despite its increasing popularity. Aim :In order to assess the metabolic effects of IF in relation to the conventional diet in individuals with type 2 diabetes, we carried out a systematic review and meta-analysis. Method: Between 1950 and August 12, 2020, randomised, diet-controlled trials assessing any IF intervention in individuals with T2DM were sought after using Embase, PubMed, and clinicaltrials.gov. Using a random-effects model to calculate pooled estimates of the absolute changes in body weight and glycated hemoglobin A1c (HbA1c) compared to a control group, we investigated the effects of IF on weight reduction and glucose-lowering. Results: Our inclusion criteria were met by seven studies (n = 338 participants; mean baseline HbA1c 8.8%, mean body mass index [BMI] 35.65). Compared to a conventional diet, IF caused a larger drop in body weight of -1.89 kg (95% CI, -2.91 to -0.86 kg), with no discernible between-study heterogeneity (I2 21.0%, P =.28). Studies with a heavier population (BMI > 36) showed a significant extra weight reduction  as did studies with a shorter duration (≤ 4 months) .When compared to a conventional diet, IF did not result in a higher decrease in HbA1c Conclusion: According to available data, individuals with type 2 diabetes may lose more weight when following an IF diet as opposed to a conventional diet, while also experiencing comparable improvements in glycemic control.

Key words: Glycated hemoglobin, body weight, type 2 diabetes, and intermittent fasting