Cytomorphological Spectrum of Palpable Breast Lesions - An Observational Study from a Tertiary Care Centre in Palakkad
Authors/Creators
- 1. Associate Professor, Dept. of Pathology, Government Medical College (IIMS), Palakkad
- 2. Assistant Professor, Dept. of General Surgery, Government Medical College (IIMS), Palakkad
- 3. Assistant Professor, Dept. of Pathology, Government Medical College (IIMS), Palakkad
- 4. Professor & Head, Department of Pathology, Government Medical College (IIMS) ,Palakkad
- 5. Lecturer, Dept. of Surgery, Government Medical College (IIMS), Palakkad
Description
Background: Fine Needle Aspiration Cytology (FNAC) is a pivotal tool in the diagnosis of breast lesions, offering a minimally invasive, rapid, and accurate method for evaluation. Objective: This study aimed to analyze the cytomorphological patterns of palpable breast lesions using FNAC and to assess its diagnostic accuracy compared to histopathology. Methods: An analytical cross-sectional study was conducted on 100 consecutive female patients with palpable breast lumps. FNAC was performed, followed by cytomorphological analysis and comparison with histopathological findings. Results: The majority of lesions were benign (60%), followed by atypical (15%), malignant (15%), and suspicious (10%). FNAC demonstrated a sensitivity of 93.3% and a specificity of 96.7%. The PPV and NPV were 93.3% and 96.7%, respectively, with significant P-values (<0.001). Cytological features like high cellularity and prominent nucleoli were strongly associated with malignancy. Discrepancies between FNAC and histopathology were low, with 3% false positives and 2% false negatives. Conclusion: FNAC proves to be a highly accurate diagnostic tool for evaluating palpable breast lesions, with a significant correlation of specific cytomorphological features with malignancy. Despite its high efficacy, the integration of FNAC with other diagnostic modalities is recommended for comprehensive breast lesion evaluation.
Abstract (English)
Background: Fine Needle Aspiration Cytology (FNAC) is a pivotal tool in the diagnosis of breast lesions, offering a minimally invasive, rapid, and accurate method for evaluation. Objective: This study aimed to analyze the cytomorphological patterns of palpable breast lesions using FNAC and to assess its diagnostic accuracy compared to histopathology. Methods: An analytical cross-sectional study was conducted on 100 consecutive female patients with palpable breast lumps. FNAC was performed, followed by cytomorphological analysis and comparison with histopathological findings. Results: The majority of lesions were benign (60%), followed by atypical (15%), malignant (15%), and suspicious (10%). FNAC demonstrated a sensitivity of 93.3% and a specificity of 96.7%. The PPV and NPV were 93.3% and 96.7%, respectively, with significant P-values (<0.001). Cytological features like high cellularity and prominent nucleoli were strongly associated with malignancy. Discrepancies between FNAC and histopathology were low, with 3% false positives and 2% false negatives. Conclusion: FNAC proves to be a highly accurate diagnostic tool for evaluating palpable breast lesions, with a significant correlation of specific cytomorphological features with malignancy. Despite its high efficacy, the integration of FNAC with other diagnostic modalities is recommended for comprehensive breast lesion evaluation.
Files
IJPCR,Vol15,Issue12,Article121.pdf
Files
(5.3 MB)
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Additional details
Dates
- Accepted
-
2023-11-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue12,Article121.pdf
- Development Status
- Active
References
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