Deciphering Macrocytic Anemia: Insights into Etiology and Hematology from South Rajasthan
Creators
- 1. Assistant Professor, Department of Pathology, Government Medical College, Chittorgarh
- 2. Senior Resident, Department of Pathology, Government Medical College, Chittorgarh
- 3. Senior Resident, Department of Pathology, Jhalawar Medical College, Jhalawar
- 4. Associate Professor, Department of Pathology, Government Medical College, Chittorgarh
Description
Introduction: Macrocytosis characterized by abnormally large erythrocytes with an increase mean corpuscular volume (MCV), is a hematological condition indicative of various underlying pathologies. It is clinically significant and can range from nutritional deficiencies to bone marrow disorders. The prevalence in India varies significantly, making a complete workup essential for determining its etiology. Material and Method: This retrospective study from May to October 2023 in South Rajasthan, India, included 142 cases. It utilized clinical history, peripheral blood film examination, and biochemical tests for diagnosis. Result: Vitamin B12 deficiency was the most common (55.63%) cause of megaloblastic macrocytic anemia and alcohol was the most common (14.79%) cause of nonmegaloblastic macrocytic anemia in this study. Conclusion: The present study suggests that vitamin B12 deficiency, alcoholism, liver disease, and drugs were the main causes of macrocytic anemia in South Rajasthan, India. The study suggests that haematological parameters along with clinical history, peripheral smear examination and biochemical analysis is useful tools for detecting and managing macrocytosis.
Abstract (English)
Introduction: Macrocytosis characterized by abnormally large erythrocytes with an increase mean corpuscular volume (MCV), is a hematological condition indicative of various underlying pathologies. It is clinically significant and can range from nutritional deficiencies to bone marrow disorders. The prevalence in India varies significantly, making a complete workup essential for determining its etiology. Material and Method: This retrospective study from May to October 2023 in South Rajasthan, India, included 142 cases. It utilized clinical history, peripheral blood film examination, and biochemical tests for diagnosis. Result: Vitamin B12 deficiency was the most common (55.63%) cause of megaloblastic macrocytic anemia and alcohol was the most common (14.79%) cause of nonmegaloblastic macrocytic anemia in this study. Conclusion: The present study suggests that vitamin B12 deficiency, alcoholism, liver disease, and drugs were the main causes of macrocytic anemia in South Rajasthan, India. The study suggests that haematological parameters along with clinical history, peripheral smear examination and biochemical analysis is useful tools for detecting and managing macrocytosis.
Files
IJPCR,Vol15,Issue12,Article79.pdf
Files
(3.6 MB)
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Additional details
Dates
- Accepted
-
2023-11-18
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue12,Article79.pdf
- Development Status
- Active
References
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