Effectiveness of Tranexamic Acid in Minimizing Perioperative Blood Loss during Orthopedic Surgeries on the Lower Limb
Creators
- 1. Associate Professor, Department of Anaesthesiology, Prathima Institute of Medical Sciences, Naganoor, Karimnagar, Telangana State.
Description
Background: The use of Tranexamic Acid (TXA) has been shown to significantly decrease blood loss in various surgical procedures and enhance survival rates in patients experiencing severe bleeding during orthopedic and trauma cases. The purpose of this study is to investigate the effects of tranexamic acid (TXA) on blood loss and hemodynamics in patients undergoing lower limb orthopedic surgeries. Methods: Selected patients were randomly allocated to two groups In Group (T), consisting of 20 patients, tranexamic acid (TXA) was administered. After a test dose of 1 mL, each patient received TXA intravenously at a dose of 15 mg/kg (up to a maximum of 1,000 mg) before the surgical incision. An additional dose of TXA at 5 mg/kg was repeated intravenously 4 hours after the initial dose (referred to as the TXA group). In Group (C), also comprising 20 patients, normal saline (placebo) was administered at the same time points as the TXA group, i.e., before the skin incision and repeated 4 hours later (referred to as the placebo group). Results: In the intraoperative period, the percentage of subjects requiring blood transfusion was remarkably lower in the tranexamic acid group, with only 10.0% needing transfusion, compared to 50.0% in the control group. This difference was found to be statistically significant (p<0.05). Thus, it can be concluded that tranexamic acid has the potential to reduce the need for blood transfusion by up to 40% in subjects. Conclusion: The results of this study demonstrated that the use of Tranexamic acid (TXA) leads to a substantial reduction of approximately 40% in blood loss and the need for blood transfusion in patients undergoing trauma surgeries. Therefore, the routine administration of TXA could be advantageous for patients undergoing Orthopedic procedures, where significant blood loss is anticipated.
Abstract (English)
Background: The use of Tranexamic Acid (TXA) has been shown to significantly decrease blood loss in various surgical procedures and enhance survival rates in patients experiencing severe bleeding during orthopedic and trauma cases. The purpose of this study is to investigate the effects of tranexamic acid (TXA) on blood loss and hemodynamics in patients undergoing lower limb orthopedic surgeries. Methods: Selected patients were randomly allocated to two groups In Group (T), consisting of 20 patients, tranexamic acid (TXA) was administered. After a test dose of 1 mL, each patient received TXA intravenously at a dose of 15 mg/kg (up to a maximum of 1,000 mg) before the surgical incision. An additional dose of TXA at 5 mg/kg was repeated intravenously 4 hours after the initial dose (referred to as the TXA group). In Group (C), also comprising 20 patients, normal saline (placebo) was administered at the same time points as the TXA group, i.e., before the skin incision and repeated 4 hours later (referred to as the placebo group). Results: In the intraoperative period, the percentage of subjects requiring blood transfusion was remarkably lower in the tranexamic acid group, with only 10.0% needing transfusion, compared to 50.0% in the control group. This difference was found to be statistically significant (p<0.05). Thus, it can be concluded that tranexamic acid has the potential to reduce the need for blood transfusion by up to 40% in subjects. Conclusion: The results of this study demonstrated that the use of Tranexamic acid (TXA) leads to a substantial reduction of approximately 40% in blood loss and the need for blood transfusion in patients undergoing trauma surgeries. Therefore, the routine administration of TXA could be advantageous for patients undergoing Orthopedic procedures, where significant blood loss is anticipated.
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IJTPR,Vol13,Issue6,Article28.pdf
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Additional details
Dates
- Accepted
-
2023-06-20
Software
References
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