Autologous Non-Cultured Non-Trypsinised Melanocyte-Keratinocyte Cell Transplantation in Treatment of Stable Vitiligo
Authors/Creators
- 1. Department of Dermatology, JLN Medical College and Associated Groups of Hospitals, Ajmer, Rajasthan, India
Description
Background: There are several modalities for the treatment of vitiligo but generally they do not result in significant cure of the disease. Autologous non-cultured non trypsinised epidermal cell suspension is simple, less time consuming and does not required special setup. Aim: To evaluate the Efficacy of Autologous Non-cultured non-trypsinised melanocyte-keratinocyte cell transplantation in treatment of stable vitiligo patches. Materials and Methods: Patient of age 18 years and above with stable vitiligo, showing no expansion of pre-existing lesion since last 6 months and who are resistant to medical therapy treated with Autologous Non-cultured non-trypsinised melanocyte-keratinocyte cell transplantation technique. Results: Excellent repigmentation (extent of repigmentation of >75%) response showed by 30% cases, Very good response (extent of repigmentation of 50%-75%) in 46%, Good response (extent of repigmentation of 25-49%) in 16%, Poor response (repigmentation <25%) in 6% at the end 20 weeks post-surgery and good colour match with surrounding pigmented area. Conclusion: Noncultured nontrypsinized melanocyte keratinocyte transplantation technique is easier, cheaper, less time consuming, less expertise needed and can cover larger body surface area with smaller grafts. This technique produces uniform and cosmetically acceptable pigmentation.
Abstract (English)
Background: There are several modalities for the treatment of vitiligo but generally they do not result in significant cure of the disease. Autologous non-cultured non trypsinised epidermal cell suspension is simple, less time consuming and does not required special setup. Aim: To evaluate the Efficacy of Autologous Non-cultured non-trypsinised melanocyte-keratinocyte cell transplantation in treatment of stable vitiligo patches. Materials and Methods: Patient of age 18 years and above with stable vitiligo, showing no expansion of pre-existing lesion since last 6 months and who are resistant to medical therapy treated with Autologous Non-cultured non-trypsinised melanocyte-keratinocyte cell transplantation technique. Results: Excellent repigmentation (extent of repigmentation of >75%) response showed by 30% cases, Very good response (extent of repigmentation of 50%-75%) in 46%, Good response (extent of repigmentation of 25-49%) in 16%, Poor response (repigmentation <25%) in 6% at the end 20 weeks post-surgery and good colour match with surrounding pigmented area. Conclusion: Noncultured nontrypsinized melanocyte keratinocyte transplantation technique is easier, cheaper, less time consuming, less expertise needed and can cover larger body surface area with smaller grafts. This technique produces uniform and cosmetically acceptable pigmentation.
Files
IJPCR,Vol16,Issue4,Article140.pdf
Files
(1.5 MB)
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Additional details
Dates
- Accepted
-
2024-03-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue4,Article140.pdf
- Development Status
- Active
References
- 1. Parsad D, Dogra S, Kanwar AJ. Quality of life in patients with vitiligo. Health Qual Life Outcomes. 2003; 1:58. 2. Lahiri K, Malakar S. The concept of stability of vitiligo: A reappraisal. Indian J Dermatol. 2012; 57:83–9. 3. Behl PN. Treatment of vitiligo with homologous thin Thiersch grafts. Curr Med Pract. 1964; 8:218–21. 4. Lahiri K. Evolution and evaluation of autologous mini punch grafting in vitiligo. Indian J Dermatol. 2009; 54:159–67. 5. Falabella R. Surgical treatment of vitiligo: Why, when and how. J Eur Acad Dermatol Venereol. 2003; 17:518–20. 6. Maleki M, Banihashemi M, Sanjari V. Efficacy of suction blister epidermal graft without phototherapy for locally stable and resistant vitiligo. Indian J Dermatol. 2012; 57:282–4. 7. Pandya V, Parmar KS, Shah BJ, Bilimoria FE. A study of autologous melanocyte transfer in treatment of stable vitiligo. Indian J Dermatol Venereol Leprol. 2005; 71:393–7. 8. Gauthier Y, Surleve-Bazeille JE. Autologous grafting with noncultured melanocytes: A simplified method for treatment of depigmented lesions. J Am Acad Dermatol. 1992; 26(2 Pt 1):191–4. 9. Kachhawa D, Kalla G. Keratinocytemelanocyte graft technique followed by PUVA therapy for stable vitiligo. Indian J Dermatol Venereol Leprol. 2008; 74:622–4.