Clinical Correlates and Microbiology of Invasive Fungal Disease in a Tertiary Care Hospital
Authors/Creators
- 1. Medical Lab Technologist, Department of Microbiology, IGIMS, Patna
- 2. Assistant Professor, Department of Microbiology, IGIMS, Patna
- 3. Multidisciplinary Research Unit, IGIMS, Patna
- 4. Professor & HOD, Department of Microbiology, IGIMS, Patna
Description
Background and objectives: There is a paucity of data in Indian literature regarding the risk factors, comprehensive clinical profile and treatment outcomes of Invasive fungal disease(IFD).Thus the aim of this study is to assess the frequency, type of IFD, clinical spectrum, risk factors, microbiological profile and outcome in patients with IFD. Methods: A cross sectional descriptive study, Study duration of One and Half Years. Patients with proven and probable IFD according to EORTC/MSG criteria were selected. Conclusion: Since elderly patients with risk factors like Type 2 diabetes, hemodialysis, prolonged ICU stay, and total parenteral nutrition were significantly associated with candidemia and mucormycosisthey need to be regularly screened for these infections. Those with underlying lung disease or prolonged steroid use need to be screened for pulmonary aspergillosis. IFD specifically those needing prolonged ICU care is associated with very high mortality.
Abstract (English)
Background and objectives: There is a paucity of data in Indian literature regarding the risk factors, comprehensive clinical profile and treatment outcomes of Invasive fungal disease(IFD).Thus the aim of this study is to assess the frequency, type of IFD, clinical spectrum, risk factors, microbiological profile and outcome in patients with IFD. Methods: A cross sectional descriptive study, Study duration of One and Half Years. Patients with proven and probable IFD according to EORTC/MSG criteria were selected. Conclusion: Since elderly patients with risk factors like Type 2 diabetes, hemodialysis, prolonged ICU stay, and total parenteral nutrition were significantly associated with candidemia and mucormycosisthey need to be regularly screened for these infections. Those with underlying lung disease or prolonged steroid use need to be screened for pulmonary aspergillosis. IFD specifically those needing prolonged ICU care is associated with very high mortality.
Files
IJPCR,Vol16,Issue1,Article201.pdf
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Additional details
Dates
- Accepted
-
2024-01-18
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue1,Article201.pdf
- Development Status
- Active
References
- 1. Arunaloke Chakrabarti et al. Overview of Opportunistic Fungal Infections in India. Jpn. J. Med. Mycol, 2008; 49:165- 172. 2. Ally, R., Schurmann, D., Kreisel, W., Carosi, G., Aguirebengoa, K., Dupont, B., Hodges, M., Troke, P. & Romero, A. J., and the Esophageal Candidiasis Study Group. A randomise control double – blind, double – dummy, multicenter trial of voriconazole and flucanazole in the treatment of esophageal candidiasis in immunocompromised patients. Clin Infect Dis. 2001; 33:1447 – 1454. 3. S. Ascioglu, J. H. Rex, B. De Pauw, J. E. Bennett, J. Bille, F. Crokaert, D. W. Denning ,1 J. P. Donnelly et al. Defining Oppurtunistic Invasive Fungal Infections in immunocompromised Patients with Cancer and Hem topoietic Stem Cell Transplants: An International Consensus. Clinical Infectious Diseases. 2002; 34: 7- 14. 4. De Pauw B, Walsh TJ, Donnelly JP, 14 et al. European Organization for Research and Treatment of Ca cer/Invasive Fungal Infections Cooperative Group; National Institute of Allergy and Infectious Diseases M cases Study Group (EORTC/MSG) Consensus Group. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/ MSG) Consensus Group. Clin Infect Dis. 2008; 46: 1813 – 1821. 5. Mahendra Pal.Morbidity and Mortality Due to Fungal Infections.Journal of Applied Microbiology and Biochemistry .2017 6. Brown GD, Denning DW, Gow NAR, Levitz SM et al. Hidden Killers: Human Fungal Infections. Sci Trans Med. 2012; 4: 1-6. 7. Ramana K V, SabithaKandi, Venkata Bharatkumar P, CH V Sharada, RatnaRaoRatna Mani, and Sanjeev D Rao, Invasive Fungal Infections: A Comprehensive Review. American Journal of Infectious Diseases and Microbiology1, 2013; 4: 64-69. 8. Ravikant, Kaur T, Gupte S et al. A review on emerging fungal infections and their significance. J Bacteriol Mycol. 2015; 1(2):39-41. 9. Chakrabarti A, Sood P, Dennening D. Estimating fungal infection burden in India using computational models: Mucormycosis burden as a case study (poster number 1044). Presented at the 23 rd ECCMID conference: Berlin, Germany, April 27-30, 2013. 10. Pappas PG, Alexander BD, Andes DR, et al. Invasive fungal infections among organ transplantrecipients: results of Transplant –Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis. 2010;50(8); 11 01-1111. 11. Guo-HaoXie, Xiang-Ming Fang,QiangFang ,Xin-Min Wu et al. Impact of invasive fungal infectionon outcome of severe sepsis: a multicenter matched cohort study in critically ill surgical patients .Critical Care.2008 12-15. 12. Singh T, Kasyap AK, Ahuwalia G, Chinna D, Sidhu SS. Epidemiology of fungal infections in critical care setting of tertiary care teaching hospital in north India: A prospective surveillance study. J ClinSci Res. 2014; 3: 14-25. 13. Ourives APJ, et al. high rate of Candida deepseated infections in patients under chronic hemodialysis with extended central venous catheter use. Rev Iberoam Micol. 2016.