Published May 2, 2024 | Version v0.28.5-beta
Software Open

broadinstitute/gatk-sv: v0.28.5-beta

  • 1. Broad Institute
  • 2. Fulcrum Genomics
  • 3. Dana-Farber Cancer Institute
  • 4. @broadinstitute
  • 5. @LokaHQ
  • 6. @populationgenomics
  • 7. @UMCCR
  • 8. MGH

Description

Updates

GatherSampleEvidence

  • Copy or move the files instead of creating symlinks in the LocalizeReads task for compatibility with CoA/TES
  • Make LocalizeReads optional
  • Make manta region bed index required
  • Make MELT scripts independent of the execution path

Main pipeline

  • Rewrite SplitVariants in TasksGenotypeBatch.wdl
  • Disable MakeCohortVcfMetrics by default
  • Find CN field for mCNVs in MainVcfQc without hard-coding order of format fields
  • Update BEDTools version to 2.31.0
  • Two small bugfixes to EvidenceQc
  • Update gatk_docker with CPX annotation changes to SVAnnotate
  • Reduce redundant docker image inputs: sv_pipeline_base_docker, sv_pipeline_hail_docker, sv_pipeline_updates_docker, sv_pipeline_rdtest_docker all now just sv_pipeline_docker

Downstream filtering

  • Reduce SVConcordance memory usage
  • Release AoU filtering model
  • Make the ploidy table a workflow output instead of an intermediate
  • Change Vapor bed preprocessing errors to warnings
  • Genotype filtering training labels and cutoff optimization

Misc.

  • Add ReshardVcf workflow
  • Setup automatic updates to WDLs on Dockstore
  • Trivial change to sv-pipeline-virtual-env
  • Add a preview version of the de-novo pipeline

Full Changelog: https://github.com/broadinstitute/gatk-sv/compare/v0.28.4-beta...v0.28.5-beta

Files

broadinstitute/gatk-sv-v0.28.5-beta.zip

Files (22.4 MB)

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