Published February 28, 2024 | Version https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article137.pdf
Journal article Open

Investigating Fetal Outcome of Jaundice in Pregnancy at a Tertiary Care Center: A Clinical Study

Authors/Creators

  • 1. Senior Resident, Department of Obstetrics & Gynaecology, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar, India
  • 2. Senior Resident, Department of Surgery, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar, India
  • 3. Associate Professor, Department of Obstetrics & Gynaecology, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar, India

Description

Background: Jaundice in pregnancy presents significant risks to both maternal and fetal health, with multifaceted etiologies ranging from benign to life-threatening conditions. Understanding the impact of maternal jaundice on fetal outcomes is crucial for effective management and intervention strategies. Methods: This retrospective observational study was conducted to investigate fetal outcomes associated with maternal jaundice in pregnancy. Data were collected from medical records of 74 pregnant individuals diagnosed with jaundice during pregnancy who received antenatal care and delivered at the tertiary care center. Variables including demographic information, gestational age at onset of jaundice, etiology of jaundice, maternal complications, fetal monitoring, mode of delivery, neonatal outcomes, and postpartum complications were analyzed. Results: The mean age of participants was 29 years (±4.5), with a range from 20 to 40 years. Gestational age at onset of jaundice ranged from 24 to 36 weeks, with a mean of 30 weeks (±3.2). Etiology of jaundice varied, with viral hepatitis (45%) and intrahepatic cholestasis of pregnancy (30%) being predominant. Maternal complications were observed in 50% of cases, with pre-eclampsia (30%) and HELLP syndrome (20%) being the most common. Abnormalities in fetal monitoring were noted in 40% of cases. Neonatal outcomes included low birth weight (55%), low APGAR scores (25%), and neonatal jaundice (35%). Significant associations were found between maternal age and mode of delivery (p = 0.034) and between etiology of jaundice and neonatal jaundice (p = 0.019). Multivariate logistic regression identified pre-eclampsia as an independent predictor of adverse fetal outcomes. Conclusion: Maternal jaundice during pregnancy poses significant risks to both maternal and fetal health, necessitating comprehensive management strategies. Early detection, close monitoring, and targeted interventions are essential for improving maternal and fetal outcomes. Recommendations: Further research is warranted to elucidate the underlying mechanisms of fetal complications associated with maternal jaundice and to develop optimized management protocols.

 

 

Abstract (English)

Background: Jaundice in pregnancy presents significant risks to both maternal and fetal health, with multifaceted etiologies ranging from benign to life-threatening conditions. Understanding the impact of maternal jaundice on fetal outcomes is crucial for effective management and intervention strategies. Methods: This retrospective observational study was conducted to investigate fetal outcomes associated with maternal jaundice in pregnancy. Data were collected from medical records of 74 pregnant individuals diagnosed with jaundice during pregnancy who received antenatal care and delivered at the tertiary care center. Variables including demographic information, gestational age at onset of jaundice, etiology of jaundice, maternal complications, fetal monitoring, mode of delivery, neonatal outcomes, and postpartum complications were analyzed. Results: The mean age of participants was 29 years (±4.5), with a range from 20 to 40 years. Gestational age at onset of jaundice ranged from 24 to 36 weeks, with a mean of 30 weeks (±3.2). Etiology of jaundice varied, with viral hepatitis (45%) and intrahepatic cholestasis of pregnancy (30%) being predominant. Maternal complications were observed in 50% of cases, with pre-eclampsia (30%) and HELLP syndrome (20%) being the most common. Abnormalities in fetal monitoring were noted in 40% of cases. Neonatal outcomes included low birth weight (55%), low APGAR scores (25%), and neonatal jaundice (35%). Significant associations were found between maternal age and mode of delivery (p = 0.034) and between etiology of jaundice and neonatal jaundice (p = 0.019). Multivariate logistic regression identified pre-eclampsia as an independent predictor of adverse fetal outcomes. Conclusion: Maternal jaundice during pregnancy poses significant risks to both maternal and fetal health, necessitating comprehensive management strategies. Early detection, close monitoring, and targeted interventions are essential for improving maternal and fetal outcomes. Recommendations: Further research is warranted to elucidate the underlying mechanisms of fetal complications associated with maternal jaundice and to develop optimized management protocols.

 

 

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Additional details

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https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article137.pdf

Dates

Accepted
2024-02-10

Software

Repository URL
https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article137.pdf
Development Status
Active

References

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