Study of Correlation between Proinflammatory Cytokines and Stress marker enzymes in Alcoholic Liver Disease Patients
Creators
- 1. Assistant Professor, Department of Pathology, Chirayu Medical College & Hospital Bhopal, Madhya Pradesh, India.
- 2. Associate Professor, Department of Biochemistry, NSCB Medical College Jabalpur, Madhya Pradesh, India
- 3. Associate Professor, Department of Biochemistry, Chirayu Medical College & Hospital Bhopal, Madhya Pradesh, India
- 4. Assistant Professor, Department of Medicine, Chirayu Medical College & Hospital Bhopal, Madhya Pradesh, India
Description
Background: Alcohol-related liver disease is a major cause of morbidity and mortality worldwide. Chronic alcohol consumption leads to hepatocellular injury, fat accumulation and liver inflammation. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which ranges initially from simple steatosis to inflammation and necrosis (steatohepatitis), to fibrosis and cirrhosis. Objectives: The study was designed to determine the effect of Pro-inflammatory cytokines & stress marker enzymes in alcoholic liver disease patients with reference to normal healthy individuals. Methods: 175 alcoholic liver disease patients were enrolled for the study & were compared to 150 normal healthy individuals of the same age from the Outdoor Patient Department of Maharaja Yeshwant Rao Hospital of Indore city. Those fulfilling inclusion & exclusion criteria were enrolled for the study & the blood samples were analysed for TNFα, IL-6, plasma MDA and SOD. Results: Significant higher concentrations of TNFα (p<0.001), IL-6 (p<0.001), and MDA (p<0.001) was demonstrated in patients with alcoholic liver disease when compared with normal healthy individuals. A significantly lower concentration of SOD (p<0.001) was demonstrated in patients with alcoholic liver disease when compared with normal healthy controls. Conclusion: Alcohol consumption causes excessive cytokine production in the liver, leading to inflammatory liver disease. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased levels of SOD and increased levels of MDA.
Abstract (English)
Background: Alcohol-related liver disease is a major cause of morbidity and mortality worldwide. Chronic alcohol consumption leads to hepatocellular injury, fat accumulation and liver inflammation. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which ranges initially from simple steatosis to inflammation and necrosis (steatohepatitis), to fibrosis and cirrhosis. Objectives: The study was designed to determine the effect of Pro-inflammatory cytokines & stress marker enzymes in alcoholic liver disease patients with reference to normal healthy individuals. Methods: 175 alcoholic liver disease patients were enrolled for the study & were compared to 150 normal healthy individuals of the same age from the Outdoor Patient Department of Maharaja Yeshwant Rao Hospital of Indore city. Those fulfilling inclusion & exclusion criteria were enrolled for the study & the blood samples were analysed for TNFα, IL-6, plasma MDA and SOD. Results: Significant higher concentrations of TNFα (p<0.001), IL-6 (p<0.001), and MDA (p<0.001) was demonstrated in patients with alcoholic liver disease when compared with normal healthy individuals. A significantly lower concentration of SOD (p<0.001) was demonstrated in patients with alcoholic liver disease when compared with normal healthy controls. Conclusion: Alcohol consumption causes excessive cytokine production in the liver, leading to inflammatory liver disease. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased levels of SOD and increased levels of MDA.
Files
IJPCR,Vol16,Issue2,Article90.pdf
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Additional details
Dates
- Accepted
-
2024-02-08
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article90.pdf
- Development Status
- Active
References
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