AOP-networkFinder - A versatile tool for FAIR reconstruction of Adverse Outcome Pathway networks from AOP-Wiki

The AOP-Wiki, a knowledge database for Adverse Outcome Pathways (AOPs), requires an efficient way to overview its content for the reconstruction of networks by experts in a given domain. We have developed a user-friendly tool using artificial intelligence, the AOP-networkFinder, that retrieves AOPs of interest, modifies them in a desirable manner, and finally visualizes networks built around the retrieved AOPs. Our tool constructs AOP networks by connecting AOPs that use the same Key Events (KEs) in a versatile but controlled manner. Genes related to these KEs are also displayed. The constructed networks can then be exported to jpg/png formats or to Cytoscape for further fine-tuning and statistical analysis. The AOP-networkFinder allows users to comprehensively identify relationships between KEs and visualize the overall structure of an AOP both quickly and easily. This is immensely beneficial to researchers who need to understand the complex interplay between different KEs and the overall pathway they are studying and helps them to build further networks of interest while logging relevant information about changes within the network. These efforts are in line with the FAIR principles, which are crucial attributes for any developed databases and tools for optimizing use and reuse in a dynamically changing landscape of AOP-Wiki.