PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION CONTAINING ORALLY DISINTEGRATING TABLETS

The orally disintegrating tablet of monteleukast prepared batches of tablets were evaluated for thickness, weigh variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro disintegration time and in-vitro drug release. Formulations were tested for the in-vitro drug release pattern (in pH 7.4 phosphate buffer). The various formulations containing superdisintegrants in different concentration will be examine the angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio of powder blend the results were found to be within prescribed limits and indicated good flowing property. In the present study four natural superdisintegrants and its concentration shall be during the preparation of ODTs. Superdisintegrants are primarily required for fast dissolving or disintegrantion of tablets for this purpose.

Keywords: Solid dispersion, Oral formulations, Disintegrating tablets, Montelukast, Bronchial asthma