Assessment of the Impact of the Amount of Contrast Material Used in Abdominal CT Examinations Regarding the Diagnosis of Appendicolith
- 1. Assistant Professor, Department of Radiology, Lord Buddha Koshi Medical College and Hospital, Saharsa, Bihar, India
- 2. Associate Professor, Department of Radiology, Lord Buddha Koshi Medical College and Hospital, Saharsa, Bihar, India
Description
Aim: The aim of the present study was to investigate the impact of the amount of contrast material used in abdominal CT examinations regarding the diagnosis of appendicolith. Methods: This was a cross-sectional study that was performed to evaluate the diagnostic value of the CT examination in patients with acute appendicitis. One hundred patients that met the inclusion criteria entered the study using census method. Demographic data of patients including age, gender were obtained. Results: In 70 patients, the CT scan findings were favorable for acute appendicitis, and the diagnosis was confirmed by the post-appendectomy pathological testing. Among the individuals undergoing CT scans, 5 false positive and 8 false negative results were recorded. The CT scan revealed that the patients had reduced peritoneal fat as well as a retrocecal appendix. The sensitivity, specificity, positive and negative predictive value of CT scans based on pathology results were 88.6%, 82.8%, 95.5%, and 78.2%, respectively, in patients with low clinical suspicion. We evaluated the CT scan and ultrasonography based on the gender of patients. Conclusion: In the clinical cases that there is suspicion of acute appendicitis, nephrolithiasis and ureterolithiasis, the present study recommends the acquisition of an abdominal CT applying however the following workflow. The CT protocol should apply first a low-dose pelvis CT scan in the region of cecum without contrast material. Subsequently, a second CT scan should be acquired with the use of oral and IV contrast.
Abstract (English)
Aim: The aim of the present study was to investigate the impact of the amount of contrast material used in abdominal CT examinations regarding the diagnosis of appendicolith. Methods: This was a cross-sectional study that was performed to evaluate the diagnostic value of the CT examination in patients with acute appendicitis. One hundred patients that met the inclusion criteria entered the study using census method. Demographic data of patients including age, gender were obtained. Results: In 70 patients, the CT scan findings were favorable for acute appendicitis, and the diagnosis was confirmed by the post-appendectomy pathological testing. Among the individuals undergoing CT scans, 5 false positive and 8 false negative results were recorded. The CT scan revealed that the patients had reduced peritoneal fat as well as a retrocecal appendix. The sensitivity, specificity, positive and negative predictive value of CT scans based on pathology results were 88.6%, 82.8%, 95.5%, and 78.2%, respectively, in patients with low clinical suspicion. We evaluated the CT scan and ultrasonography based on the gender of patients. Conclusion: In the clinical cases that there is suspicion of acute appendicitis, nephrolithiasis and ureterolithiasis, the present study recommends the acquisition of an abdominal CT applying however the following workflow. The CT protocol should apply first a low-dose pelvis CT scan in the region of cecum without contrast material. Subsequently, a second CT scan should be acquired with the use of oral and IV contrast.
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Additional details
Dates
- Accepted
-
2023-09-20
Software
References
- 1. Livingston EH, Fomby TB, Woodward WA, Haley RW. Epidemiological similarities between appendicitis and diverticulitis suggesting a common underlying pathogenesis. Archives of Surgery. 2011 Mar 1;146(3):308-14. 2. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Annals of surgery. 2007 Jun;245(6):886. 3. Hansson J, Körner U, Khorram-Manesh A, Solberg A, Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Journal of British Surgery. 2009 May;96(5):473-81. 4. Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Tuominen R, Hurme S, Virtanen J, Mecklin JP, Sand J. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. Jama. 2015 Jun 16;3 130020(23):2340-8. 5. Svensson JF, Patkova B, Almström M, Naji H, Hall NJ, Eaton S, Pierro A, Wester T. Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. 6. Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granström L. Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World journal of surgery. 2006 Jun;30:1033-7. 7. Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, Karoui M, Alves A, Dousset B, Valleur P, Falissard B. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. The Lancet. 2011 May 7;377 (9777):1573-9. 8. Harnoss JC, Zelienka I, Probst P, Grummich K, Mueller-Lantzsch C, Harnoss JM, Ulrich A, Buechler MW, Diener MK. Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42 015016882). Annals of surgery. 2017 May 1;2 650020(5):889-900. 9. Poprom N, Numthavaj P, Wilasrusmee C, Rattanasiri S, Attia J, McEvoy M, Thakkinstian A. The efficacy of antibiotic treatment versus surgical treatment of uncomplicated acute appendicitis: Systematic review and network metaanalysis of randomized controlled trial. The American Journal of Surgery. 2019 Jul 1;218 (1):192-200. 10. Sallinen V, Akl EA, You JJ, Agarwal A, Shoucair S, Vandvik PO, Agoritsas T, HeelsAnsdell D, Guyatt GH, Tikkinen KA. Metaanalysis of antibiotics versus appendicectomy for non-perforated acute appendicitis. Journal of British Surgery. 2016 May;103(6):656-67. 11. Salminen P, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Virtanen J. Fiveyear follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. Jama. 2018 Sep 25;3 20(12):1259-65. 12. Sippola S, Grönroos J, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Salminen P. Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. Journal of British Surgery. 2017 Sep;104(10):1355-61. 13. Karul M, Berliner C, Keller S, Tsui TY, Yamamura J. Imaging of appendicitis in adults. InRöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 2014 Apr 23 (pp. 551-558). © Georg Thieme Verlag KG. 14. Löbrich M, Rief N, Kühne M, Heckmann M, Fleckenstein J, Rübe C, Uder M. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proceedings of the National Academy of Sciences. 2005 Jun 21;102(25):8984-9. 15. Awayshih MMA, Nofal MN and Yousef AJ. Eval- uation of Alvarado score in diagnosing acute appendicitis. Pan Afr Med J 2019; 34: 15. 16. Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, Boermeester M, Sartelli M, Coccolini F, Tarasconi A, De' Angelis N, We- ber DG, Tolonen M, Birindelli A, Biffl W, Moore EE, Kelly M, Soreide K, Kashuk J, Ten Broek R, Gomes CA, Sugrue M, Davies RJ, Damaskos D, Leppäniemi A, Kirkpatrick A, Peitzman AB, Fra- ga GP, Maier RV, Coimbra R, Chiarugi M, Sgan- ga G, Pisanu A, De' Angelis GL, Tan E, Van Goor H, Pata F, Di Carlo I, Chiara O, Litvin A, Campa- nile FC, Sakakushev B, Tomadze G, Demetrashvili Z, Latifi R, Abu-Zidan F, Romeo O, Segovia- Lohse H, Baiocchi G, Costa D, Rizoli S, Balogh ZJ, Bendinelli C, Scalea T, Ivatury R, Velmahos G, Andersson R, Kluger Y, Ansaloni L and Cat- ena F. Diagnosis and treatment of acute ap- pendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg 2020; 15: 27. 17. Krzyzak M, Mulrooney SM. Acute appendicitis review: background, epidemiology, diagnosis, and treatment. Cureus. 2020 Jun 11;12(6). 18. Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: a review. Jama. 2021 Dec 14;326(22): 2299-311. 19. Podda M, Pisanu A, Sartelli M, Coccolini F, Damaskos D, Augustin G, Khan M, Pata F, De Simone B, Ansaloni L, Catena F. Diagnosis of acute appendicitis based on clinical scores: is it a myth or reality?. Acta Bio Medica: Atenei Parmensis. 2021;92(4). 20. Pogorelić Z, Domjanović J, Jukić M, Poklepović Peričić T. Acute appendicitis in children younger than five years of age: diagnostic challenge for pediatric surgeons. Surgical infections. 2020 Apr 1;21(3):239-45. 21. Depetris MA, Chamorro EM, Sanz LI, Merino JA, Cuellar ER, Nacenta SB. The usefulness and positive predictive value of ultrasonography and computed tomography in the diagnosis of acute appendicitis in adults: a retrospective study. Radiología (English Edition). 2022 Nov 1;64(6):506-15. 22. Fu J, Zhou X, Chen L, Lu S. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis. Frontiers in Surgery. 2021 Jun 28; 8:707160. 23. Hoffmann JC, Trimborn CP, Hoffmann M, Schröder R, Förster S, Dirks K, Tannapfel A, Anthuber M, Hollerweger A. Classification of acute appendicitis (CAA): Treatment directed new classification based on imaging (ultrasound, computed tomography) and pathology. International Journal of Colorectal Disease. 2021 Nov;36(11):2347-60. 24. Zisman A, Novi B, Gaughan J, Carr L. Factors affecting utilization of CT scan following ultrasound evaluation of suspected appendicitis. Journal of Osteopathic Medicine. 2022 Mar 3; 10020220020(6):313-8. 25. Karul M, Berliner C, Keller S, Tsui TY, Yamamura J. Imaging of appendicitis in adults. InRöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 2014 Apr 23 (pp. 551-558). © Georg Thieme Verlag KG.