A Hospital Based Observational Study to Assess the Association of Dengue Serology with Variations in RBC Parameters
Authors/Creators
- 1. Tutor, Department of Pathology, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India
- 2. Professor and HOD, Department of Pathology, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India
Description
Aim: The aim of the present study was to assess the association of dengue serology with variations in RBC
parameters.
Methods: The present study was conducted in the Department of Pathology. Out of 200 total study populations,
100 were dengue positive and 100 were dengue negative.
Results: Multiple logistic regression showed thrombocytopenia, leukopenia (ORA = 0.999; p < 0.001), glucose
level, aspartate aminotransferase and monocytosis as significant parameters in the NS1-only positive group.
Similarly, thrombocytopenia, glucose level and aspartate aminotransferase were significant in IgM-only positive
patients. Moreover, thrombocytopenia, leukopenia, glucose, aspartate aminotransferase and lymphopenia were
independent predictors in both NS1 + IgM positive groups.
Conclusion: The study found that certain hematological and biochemical parameters can predict the outcome of
dengue infection, which can assist physicians in the diagnosis and proper patient management. Parameters, such
as thrombocytopenia, AST, hyperglycemia, and leukopenia with monocytosis (in the NS1-only phase);
thrombocytopenia, elevated AST, and high blood glucose (in the IgM-only phase); and thrombocytopenia,
elevated AST, high blood glucose, and leukopenia with lymphopenia (in the dual-positive/both NS1 + IgM phase),
can provide insight into dengue positivity and help with patient management.
Abstract (English)
Aim: The aim of the present study was to assess the association of dengue serology with variations in RBC
parameters.
Methods: The present study was conducted in the Department of Pathology. Out of 200 total study populations,
100 were dengue positive and 100 were dengue negative.
Results: Multiple logistic regression showed thrombocytopenia, leukopenia (ORA = 0.999; p < 0.001), glucose
level, aspartate aminotransferase and monocytosis as significant parameters in the NS1-only positive group.
Similarly, thrombocytopenia, glucose level and aspartate aminotransferase were significant in IgM-only positive
patients. Moreover, thrombocytopenia, leukopenia, glucose, aspartate aminotransferase and lymphopenia were
independent predictors in both NS1 + IgM positive groups.
Conclusion: The study found that certain hematological and biochemical parameters can predict the outcome of
dengue infection, which can assist physicians in the diagnosis and proper patient management. Parameters, such
as thrombocytopenia, AST, hyperglycemia, and leukopenia with monocytosis (in the NS1-only phase);
thrombocytopenia, elevated AST, and high blood glucose (in the IgM-only phase); and thrombocytopenia,
elevated AST, high blood glucose, and leukopenia with lymphopenia (in the dual-positive/both NS1 + IgM phase),
can provide insight into dengue positivity and help with patient management.
Files
IJCPR,Vol16,Issue2,Article34.pdf
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Additional details
Dates
- Accepted
-
2024-02-25