MR Spectroscopy and Post-Operative Histopathology in Diagnosis of IntraCranial Space Occupying Lesions – A Comparative Study

Description

Abstract (English)

Aim: The aim of the present study was to assess the various MR Spectroscopy findings in Intra-cranial space
occupying lesions that help to make a clinical diagnosis and effectiveness of MR Spectroscopy in diagnosing
Intra-cranial space occupying lesions and its accuracy as confirmed by post-operative histopathological findings.
Methods: The present study was conducted in the Department of Neurosurgery, Government TD Medical
College, Alappuzha, Kerala. 18 months after Institutional Ethics Committee approval. Data was collected for a
period of 12 months and analysis was done at the end of 12 months. All patients admitted with intra-cranial space
occupying lesion and undergoing surgery under Department of Neurosurgery, Government TD Medical College,
Alappuzha, Kerala and who were willing to participate in the study.
Results: It was observed that out of the total 50 cases participated in the study, most of the cases i.e. 9 (18%) each
, belong to the age group of 31-40 years and 51-60 years, followed by 8 (16%) each in age group of 41-50 years
and 61-70 years. Out of total 50 cases participated in the study, 32 (64%) were males and 18 (36%) were females,
with male to female ratio 1.8:1. Most common diagnosis among the participated cases was Glioma in 17 (34%)
cases followed by meningioma in 11 (22%) cases, abscess in 3 (6%) cases and metastasis, pituitary tumour,
lymphoma, pineal tumour each in 2 (4%) cases. After Histopathological examination, most common finding
observed was Glioma in 17 (34%) cases followed by meningioma in 11 (22%) cases.
Conclusion: The present study has shown MRS can differentiate neoplastic from the non-neoplastic intracranial
lesions, as well as diagnose various lesions based on metabolite ratios and spectrum, helps in better tissue
characterization improving the accuracy and confidence level of neurosurgeons in their diagnosis.