Comparative Analysis of Serum Lipid Profiles in Patients with Depressive Disorder
Authors/Creators
- 1. Assistant Professor, Department of Psychiatry, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat, India
Description
Background and Aim: Evidence seems to suggest that dysfunction in many biological functions is associated with major depressive disorder (MDD). Literature suggests a possible link between different lipid parameters and depression. The study aimed to compare the serum lipid parameters of psychiatric depressed patients undergoing therapy with those of normal controls. Material and Methods: The investigation was conducted over duration of one year. A cohort of 100 individuals diagnosed with depression, aged between 25 and 50 years, were chosen from the Psychiatry outpatient department. The control group of the study included one hundred healthy individuals who were matched based on gender and age group and did not have depression or use any other medication. The levels of serum total cholesterol (TC) and triglycerides (TG) were determined using spectrophotometry on an auto analyzer. The measurement of HDL-C was conducted using the Dextran sulphate Mg2+ precipitation technique. The calculation of LDL-C was performed using the Friedwald equation. Results: The average age of the patients included in the study group was determined to be 30.22 ± 08.10 years, whereas the age in the control group was determined to be 33.89 ± 07.22 years. The average HDL cholesterol level of 100 participants in the study group was 49.62 ± 15.76 mg/dl, whereas it was 45.23 ± 2.12 mg/dl for the 100 participants in the control group. The average total cholesterol (TC) level of 100 participants in the study group was 180.12 ± 32.98 mg/dl, whereas it was 220.43 ± 79.29 mg/dl for the 100 participants in the control group. Conclusion: Individuals diagnosed with Major Depressive Disorder exhibit a greater occurrence and frequency of hyperlipidemia compared to the general population. Individuals with serum lipid profile abnormalities are at an increased risk of developing cardiovascular disease.
Abstract (English)
Background and Aim: Evidence seems to suggest that dysfunction in many biological functions is associated with major depressive disorder (MDD). Literature suggests a possible link between different lipid parameters and depression. The study aimed to compare the serum lipid parameters of psychiatric depressed patients undergoing therapy with those of normal controls. Material and Methods: The investigation was conducted over duration of one year. A cohort of 100 individuals diagnosed with depression, aged between 25 and 50 years, were chosen from the Psychiatry outpatient department. The control group of the study included one hundred healthy individuals who were matched based on gender and age group and did not have depression or use any other medication. The levels of serum total cholesterol (TC) and triglycerides (TG) were determined using spectrophotometry on an auto analyzer. The measurement of HDL-C was conducted using the Dextran sulphate Mg2+ precipitation technique. The calculation of LDL-C was performed using the Friedwald equation. Results: The average age of the patients included in the study group was determined to be 30.22 ± 08.10 years, whereas the age in the control group was determined to be 33.89 ± 07.22 years. The average HDL cholesterol level of 100 participants in the study group was 49.62 ± 15.76 mg/dl, whereas it was 45.23 ± 2.12 mg/dl for the 100 participants in the control group. The average total cholesterol (TC) level of 100 participants in the study group was 180.12 ± 32.98 mg/dl, whereas it was 220.43 ± 79.29 mg/dl for the 100 participants in the control group. Conclusion: Individuals diagnosed with Major Depressive Disorder exhibit a greater occurrence and frequency of hyperlipidemia compared to the general population. Individuals with serum lipid profile abnormalities are at an increased risk of developing cardiovascular disease.
Files
IJPCR,Vol16,Issue3,Article219.pdf
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Additional details
Dates
- Accepted
-
2024-02-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue3,Article219.pdf
- Development Status
- Active
References
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