Published April 11, 2024 | Version v.0.0
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oshritshtossel/miMic: miMic tool code


This code is attached to the paper "mi-Mic: a novel multi-layer statistical test for microbiota-disease associations". MiMic (Mann-Whitney iMage Microbiome), a novel approach for microbiome differential abundance analysis, tackles the key challenges of such statistical tests: a large number of tests, sparsity, varying abundance scales, and taxonomic relationships. Mimic first converts microbial counts to a cladogram of means. It then applies apriori tests on the upper levels of the cladogram to detect overall relationships. Finally, it performs a Mann-Whitney test on paths that are consistently significant along the tree or on the leaves. MiMic has much higher true to false positive ratios than existing tests, as measured by a new real to shuffle positive score.



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