Gentamicin palmitate as a new antibiotic formulation for mixing with bone tissue and local release
Authors/Creators
- 1. Experimental Orthopaedics, Medical University Innsbruck, Salurner Strasse 15, 6020 Innsbruck, Austria
- 2. Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria
- 3. Heraeus Medical GmbH, Wehrheim, Germany
Description
Abstract During surgery with bone grafting, the
impaction of bone tissue creates an avascular area
where local circulation is disrupted. If infections
arise, they may prevent systemically administered
antibiotics from reaching the infected bone. In this
study we evaluated gentamicin palmitate (GP)
mixed with gentamicin sulfate (GS) as a coating
for bone chips (BCh). The efficacy of the coated
BCh was measured by gentamicin base release tests
using B. subtilis, S. epidermidis and S. aureus.
Gentamicin base release was evaluated in phosphate-
buffered saline for up to 7 days using B.
subtilis bioassay. Antimicrobial efficacy was tested
with S. aureus and S. epidermidis. A significant
difference on the release of gentamicin base
between GS and GS ? GP was observed. S.
epidermidis are significantly more susceptible to
GS ? GP and GS than S. aureus. BCh can act as
gentamicin carriers and showed efficacy against
S. aureus and S. epidermidis.
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