ANALYTICAL METHODS USED FOR ESTIMATION OF ELTROMBOPAG OLAMINE – AN OVERVIEW

Analytical techniques have been developed for the quantitative determination of eltrombopag olamine in bulk and tablet dosage forms. Reverse phase chromatography, liquid chromatography–mass spectrometry, UPLC-MS/MS, HPLC, and RP-UPLC are some of the analytical techniques used for determination of eltrombopag olamine. All the methods produced good results in terms of selectivity and sensitivity. The methods were validated and found to be precise, accurate, and robust. The methods are suitable for pharmaceutical analysis and can be used to study the pharmacokinetics of eltrombopag in humans. The article concluded that the developed methods are useful for the determination of eltrombopag olamine in the pharmaceutical industry for drug development, process validation, and quality control.

Key words: Eltrombopag olamine, RP-UPLC, validation, chronic immune thrombocytopenia.